Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels

• Published in: Journal of dermatological science Vol. 25; no. 2; pp. 116 - 126
• Main Authors: Wakugawa, Motoshi, Hayashi, Keiko, Nakamura, Koichiro, Tamaki, Kunihiko
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.02.2001
• Subjects: Adult; Antigens, Dermatophagoides; Atopic dermatitis; Cells, Cultured; Cytokines - antagonists & inhibitors; Cytokines - metabolism; Dermatitis, Atopic - blood; Dermatitis, Atopic - immunology; Female; Glycoproteins - immunology; Humans; Immunoglobulin E - blood; Immunosuppressive Agents - pharmacology; Interferon-gamma - antagonists & inhibitors; Interferon-gamma - blood; Interleukin-13; Interleukin-13 - antagonists & inhibitors; Interleukin-13 - blood; Interleukin-4; Interleukin-4 - antagonists & inhibitors; Interleukin-4 - blood; Interleukin-5 - antagonists & inhibitors; Interleukin-5 - blood; Male; Monocytes - metabolism; Mononuclear leukocytes; Reference Values; Tacrolimus; Tacrolimus - pharmacology; Th1 Cells - metabolism; Th2 cells; Th2 Cells - metabolism; Time Factors; IFN, interferon; Interleukin-4; Dp, dermatophagoides pteronyssinus; Tacrolimus; Atopic dermatitis; IL, interleukin; Mononuclear leukocytes; Interleukin-13; AD, atopic dermatitis; Th2 cells; DME, dust mite extract; PBMC, peripheral blood mononuclear cell

There have been several reports about Th1/Th2 imbalances in atopic dermatitis (AD), but there have been few precise investigations about the differences between Th1 and Th2 cytokine secretion patterns of peripheral blood mononuclear cells (PBMCs) in such patients. We cultured PBMCs, taken from AD pa...