PopLDdecay: a fast and effective tool for linkage disequilibrium decay analysis based on variant call format files

Abstract Motivation Linkage disequilibrium (LD) decay is of great interest in population genetic studies. However, no tool is available now to do LD decay analysis from variant call format (VCF) files directly. In addition, generation of pair-wise LD measurements for whole genome SNPs usually result...

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Bibliographic Details
Published inBioinformatics Vol. 35; no. 10; pp. 1786 - 1788
Main Authors Zhang, Chi, Dong, Shan-Shan, Xu, Jun-Yang, He, Wei-Ming, Yang, Tie-Lin
Format Journal Article
LanguageEnglish
Published England Oxford University Press 15.05.2019
Subjects
bioinformatics
computer software
genome
linkage disequilibrium
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Summary:Abstract Motivation Linkage disequilibrium (LD) decay is of great interest in population genetic studies. However, no tool is available now to do LD decay analysis from variant call format (VCF) files directly. In addition, generation of pair-wise LD measurements for whole genome SNPs usually resulting in large storage wasting files. Results We developed PopLDdecay, an open source software, for LD decay analysis from VCF files. It is fast and is able to handle large number of variants from sequencing data. It is also storage saving by avoiding exporting pair-wise results of LD measurements. Subgroup analyses are also supported. Availability and implementation PopLDdecay is freely available at https://github.com/BGI-shenzhen/PopLDdecay.
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ISSN:1367-4803
1367-4811
1460-2059
1367-4811
DOI:10.1093/bioinformatics/bty875