Comparative analysis of leg and antenna development in wild-type and homeotic Drosophila melanogaster

• Published in: Development Genes and Evolution Vol. 213; no. 7; pp. 319 - 327
• Main Authors: Cummins, Mark, Pueyo, Jose I., Greig, Steve A., Couso, Juan Pablo
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.07.2003
• Subjects: Animals; Antennae; Antennapedia Homeodomain Protein; Biological Evolution; Comparative analysis; Conservation; Drosophila; Drosophila melanogaster - embryology; Drosophila melanogaster - genetics; Drosophila Proteins; Extremities - embryology; Gene Expression Regulation, Developmental; Genes; Genes, Homeobox - genetics; Genes, Insect; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; HOX gene; Insects; Leg; Morphogenesis - physiology; Nuclear Proteins; Structural Homology, Protein; Transcription Factors - metabolism; Transformation, Genetic

The insect leg and antenna are thought to be homologous structures, evolved from a common ancestral appendage. The homeotic transformations of antenna to leg in Drosophila produced by mutation of the Hox gene Antennapedia are position-specific, such that every particular antenna structure is transfo...