Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

• Published in: Mechanisms of ageing and development Vol. 133; no. 11-12; pp. 675 - 685
• Main Authors: Olivieri, Fabiola, Spazzafumo, Liana, Santini, Gabriele, Lazzarini, Raffaella, Albertini, Maria Cristina, Rippo, Maria Rita, Galeazzi, Roberta, Abbatecola, Angela Marie, Marcheselli, Fiorella, Monti, Daniela, Ostan, Rita, Cevenini, Elisa, Antonicelli, Roberto, Franceschi, Claudio, Procopio, Antonio Domenico
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.11.2012; Elsevier
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Biological and medical sciences; Biomarkers - metabolism; C-Reactive Protein - biosynthesis; Cardiovascular Diseases - metabolism; Centenarians; Centenarians offspring; Circulating microRNA; Circulating miR-21; Cohort Studies; Development. Metamorphosis. Moult. Ageing; Fibrinogen - biosynthesis; Fundamental and applied biological sciences. Psychology; Humans; Inflammation; MicroRNAs - blood; MicroRNAs - metabolism; Middle Aged; Models, Statistical; Oligonucleotide Array Sequence Analysis; Protein-Serine-Threonine Kinases - metabolism; Receptors, Transforming Growth Factor beta - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Centenarians; Circulating microRNA; Centenarians offspring; Circulating miR-21; Gene silencing; Vertebrata; Senescence; Mammalia; Micro RNA; Age

► Profiling of circulating miRs revealed age-related differences. ► MiR-21 was decreased in centenarians and increased in CVD patients. ► A significant correlation between miR-21 and C-reactive protein and fibrinogen was observed. ► MiR-21 appears as circulating biomarker of inflammation in aging pr...