Characterization of Induced Current Density During Transcorneal Electrical Stimulation to Promote Neuroprotection in the Degenerating Retina

• Published in: IEEE transactions on biomedical engineering Vol. 71; no. 11; pp. 3221 - 3231
• Main Authors: Iseri, Ege, Kosta, Pragya, Pollalis, Dimitrios, Lo, Pei-An, Tew, Ben Yi, Louie, Stan, Salhia, Bodour, Humayun, Mark, Lazzi, Gianluca
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.11.2024; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Amplitudes; Animals; Bioelectric phenomena; Bioelectromagnetics; Cadavers; Cell culture; Computational modeling; Computational neuroscience; Computer Simulation; Cornea; Cornea - physiology; Current density; Degeneration; Design optimization; Electric fields; Electric potential; Electric Stimulation - methods; Electric Stimulation Therapy - methods; Electrical properties; Electrical stimulation; Electrical stimuli; Electrodes; Electrophysiology; In vitro methods and tests; In vivo methods and tests; Neuroprotection; Neuroprotection - physiology; Photoreceptors; Rats; Retina; Retina - physiology; Retina - physiopathology; Retina - radiation effects; Retinal degeneration; Retinal Degeneration - physiopathology; Retinal Degeneration - therapy; Simulation; Stimulation; Swine; transcorneal electrical stimulation; Voltage
• ISSN: 0018-9294; 1558-2531; 1558-2531
• DOI: 10.1109/TBME.2024.3412814

Objective: Transcorneal electrical stimulation (TES) is a promising approach to delay retinal degeneration by inducing extracellular electric field-driven neuroprotective effects within photoreceptors. Although achieving precise electric field control is feasible in vitro, characterizing these field...