Highly concordant coexpression of aromatase and estrogen receptor β in non–small cell lung cancer

• Published in: Human pathology Vol. 41; no. 2; pp. 190 - 198
• Main Authors: Abe, Keiko, MD, PhD, Miki, Yasuhiro, PhD, Ono, Katsuhiko, CT, Mori, Miki, CT, Kakinuma, Hideaki, Kou, Yuki, Kudo, Nobutaka, Koguchi, Masashi, Niikawa, Hiromichi, MD, PhD, Suzuki, Satoshi, MD, PhD, Evans, Dean B, Sugawara, Shunichi, MD, Suzuki, Takashi, MD, PhD, Sasano, Hironobu, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2010; Elsevier
• Subjects: Aged; Aged, 80 and over; Allred score; Aromatase; Aromatase - metabolism; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Chi-Square Distribution; Estrogen Receptor beta - metabolism; Estrogen receptor β; Female; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Ki-67 Antigen - metabolism; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Medical sciences; Middle Aged; Neoplasm Staging; Non–small cell lung cancer; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Pneumology; Receptors, Progesterone - metabolism; Sex Factors; Tumors of the respiratory system and mediastinum; Estrogen receptor β; Non–small cell lung cancer; Allred score; Aromatase; Lung disease; Enzyme; Respiratory disease; Lung cancer; Coexpression; Malignant tumor; Estrogen synthase; non-small cell lung carcinoma; Anatomic pathology; Score; Non-small cell lung cancer; Bronchus disease; Cancer

Summary Estrogen receptor expression has been reported in non–small cell lung cancer. We examined the correlation between aromatase, a key enzyme in the synthesis of estrogen, and estrogen receptor expressions in 105 non–small cell lung cancer cases. All patients were older than 60 years, and all fe...