Involvement of free radical-mediated oxidation in the pathogenesis of pseudoexfoliation syndrome detected based on specific hydroxylinoleate isomers

• Published in: Free radical biology & medicine Vol. 147; pp. 61 - 68
• Main Authors: Umeno, Aya, Tanito, Masaki, Kaidzu, Sachiko, Takai, Yasuyuki, Yoshida, Yasukazu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2020
• Subjects: Exfoliation syndrome; Free radical-mediated oxidation; Glaucoma; Hydroxylinoleate isomers; Pseudoexfoliation syndrome; Glaucoma; AA; POAG; SBP; EXS; Exfoliation syndrome; Free radical-mediated oxidation; HODE; IOP; VA; BP; ECM; HETE; RGC; DBP; EX; HPODE; OAG; EXG; LA; Pseudoexfoliation syndrome; TM; Hydroxylinoleate isomers

We reported previously that enzymatic and singlet oxygen-mediated fatty acid oxidation may be major oxidation pathways in subjects with primary open angle glaucoma, based on measurement of serum levels of hydroxylinoleate (HODE) and hydroxyarachidonate (HETE) isomers after reduction and saponificati...