Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

• Published in: Free radical biology & medicine Vol. 168; pp. 129 - 141
• Main Authors: Liu, Tian, Lv, Yi-Fei, Zhao, Jing-Long, You, Qi-Dong, Jiang, Zheng-Yu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.05.2021
• Subjects: Cellular protection; NRF2; Oxidative stress; Phosphorylation; Posttranslational modification; Regulation; Posttranslational modification; Oxidative stress; Phosphorylation; Regulation; Cellular protection; NRF2

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the activation of the antioxidant cytoprotective pathway and other important physiological processes to maintain cellular homeostasis. The dysregulation of NRF2 activity plays a role in various diseases, such a...