UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 6; p. 502
• Main Authors: Giorgio, Carmine, Allodi, Marika, Palese, Simone, Grandi, Andrea, Tognolini, Massimiliano, Castelli, Riccardo, Lodola, Alessio, Flammini, Lisa, Cantoni, Anna Maria, Barocelli, Elisabetta, Bertoni, Simona
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.05.2021; MDPI
• Subjects: Colon; Cytokines; Drug dosages; EphA2; ephrin-A1-Fc; Gene expression; Inflammation; Inflammatory bowel disease; Investigations; Kinases; Lymphocytes; Neutrophils; Proteins; splenocytes; sulfasalazine; TNBS-induced colitis

Eph receptors, comprising A and B classes, interact with cell-bound ephrins generating bidirectional signaling. Although mainly related to carcinogenesis and organogenesis, the role of Eph/ephrin system in inflammation is growingly acknowledged. Recently, we showed that EphA/ephrin-A proteins can mo...