Virgin olive oil and its phenol fraction modulate monocyte/macrophage functionality: a potential therapeutic strategy in the treatment of systemic lupus erythematosus

• Published in: British journal of nutrition Vol. 120; no. 6; pp. 681 - 692
• Main Authors: Aparicio-Soto, Marina, Montserrat-de la Paz, Sergio, Sanchez-Hidalgo, Marina, Cardeno, Ana, Bermudez, Beatriz, Muriana, Francisco J. G., Alarcon-de-la-Lastra, Catalina
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.09.2018
• Subjects: Animals; Arthritis; Autoimmune diseases; Chronic conditions; Cytokines; Deregulation; Diet; Disease; humans; Immune response; Immune system; In vivo methods and tests; Inflammation; Inflammatory diseases; Innate immunity; Kinases; Laboratories; Lipopolysaccharides; Lupus; lupus erythematosus; Macrophages; Metabolism; Mice; Monocytes; Nitric oxide; nitrites; Nutritional Immunology; Oils & fats; Olive oil; patients; Peritoneum; peroxisome proliferator-activated receptor gamma; phenol; Phenols; phenotype; Phenotypes; Pristane; Proteins; Regulators; Rodents; secretion; Signal transduction; Sunflower oil; Systemic lupus erythematosus; therapeutics; TLR4 protein; Toll-like receptor 4; Toll-like receptors; virgin olive oil; volunteers; Monocytes; Systemic lupus erythematosus; Macrophages; Virgin olive oil; Immunomodulation; Dietary phenols; CCR2 C-C chemokine receptor type 2; SOD diet containing sunflower oil; iNOS inducible nitric oxide synthase; VOO virgin olive oil; RPMI Roswell Park Memorial Institute; VOOD diet containing virgin olive oil; TLR4 Toll-like receptor 4; LPS lipopolysaccharide; PF phenol fraction; SLE systemic lupus erythematosus

Monocytes and macrophages are critical effectors and regulators of inflammation and innate immune response, which appear altered in different autoimmune diseases such as systemic lupus erythematosus (SLE). Recent studies suggested that virgin olive oil (VOO) and particularly its phenol compounds mig...