Mucosa-Associated Faecalibacterium prausnitzii Phylotype Richness Is Reduced in Patients with Inflammatory Bowel Disease

• Published in: Applied and Environmental Microbiology Vol. 81; no. 21; pp. 7582 - 7592
• Main Authors: Lopez-Siles, Mireia, Martinez-Medina, Margarita, Abellà, Carles, Busquets, David, Sabat-Mir, Miriam, Duncan, Sylvia H., Aldeguer, Xavier, Flint, Harry J., Garcia-Gil, L. Jesús
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.11.2015
• Subjects: Bacteria; Biochemical markers; Biomarkers; Biopsy; Clostridiales - classification; Clostridiales - genetics; Clostridiales - isolation & purification; Cluster Analysis; Colorectal carcinoma; Denaturing Gradient Gel Electrophoresis; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; DNA, Ribosomal - chemistry; DNA, Ribosomal - genetics; Faecalibacterium prausnitzii; Gastrointestinal diseases; Genetic Variation; Genotype; Humans; Inflamació; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - microbiology; Intestinal Mucosa - microbiology; Intestins; Marcadors bioquímics; Microbial Ecology; Microbiology; Molecular Sequence Data; Pathogenesis; Phylogeny; Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA, Ribosomal, 16S - genetics; Sequence Analysis, DNA

Faecalibacterium prausnitzii depletion in intestinal diseases has been extensively reported, but little is known about intraspecies variability. This work aims to determine if subjects with gastrointestinal disease host mucosa-associated F. prausnitzii populations different from those hosted by heal...