Vascular brain-derived neurotrophic factor pathway in rats with adjuvant-induced arthritis: Effect of anti-rheumatic drugs

• Published in: Atherosclerosis Vol. 274; pp. 77 - 85
• Main Authors: Pedard, Martin, Quirié, Aurore, Totoson, Perle, Verhoeven, Frank, Garnier, Philippe, Tessier, Anne, Demougeot, Céline, Marie, Christine
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.07.2018; Elsevier
• Subjects: Adjuvant-induced arthritis; Animals; Anti-rheumatic drugs; Antirheumatic Agents - pharmacology; Aorta - drug effects; Aorta - metabolism; Arthritis, Experimental - chemically induced; Arthritis, Experimental - drug therapy; Arthritis, Experimental - metabolism; Arthritis, Experimental - physiopathology; Brain-Derived Neurotrophic Factor - metabolism; Cardiology and cardiovascular system; Cyclooxygenase Inhibitors - pharmacology; Freund's Adjuvant; Glucocorticoids - pharmacology; Human health and pathology; Immunosuppressive Agents - pharmacology; Life Sciences; Male; Nitric Oxide - metabolism; Nitric Oxide Synthase Type III - metabolism; Phosphorylation; Rats, Inbred Lew; Receptor, trkB - metabolism; Signal Transduction - drug effects; Vascular BDNF; Vasodilation - drug effects; Vascular BDNF; Adjuvant-induced arthritis; Anti-rheumatic drugs; nerve growth-factor; nitric-oxide synthase; tnf-alpha; dysfunction; cells; bdnf; improves endothelial function; cardiovascular risk; rheumatoid-arthritis; inflammatory arthritis

In rheumatoid arthritis, the control of both disease activity and standard cardiovascular (CV) risk factors is expected to attenuate the increased CV risk. Evidence that brain-derived neurotrophic factor (BDNF) plays a role in vascular biology led us to investigate the vascular BDNF pathway in arthr...