A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse?
This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosis have a common cause in pulse-induced capillary haemorrhage. All three conditions are age-related and characterised by insidious onset, uncertainty about their cause, exacerbat...
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Published in | Biomedicines Vol. 12; no. 9; p. 1969 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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01.09.2024
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Abstract | This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosis have a common cause in pulse-induced capillary haemorrhage. All three conditions are age-related and characterised by insidious onset, uncertainty about their cause, exacerbation by hypertension, resistance to treatment and the relentlessness of their progression. We argue that the three conditions are the clinical outcomes of damage caused by pulse-induced haemorrhage from capillaries. The damage, first detectable in mid-life, creates first mild and then severe symptoms of cognitive, renal and pulmonary dysfunction. We also review evidence that in all three organs there has developed, by young adulthood, a reserve of tissue that enables them to function well, despite the 'heartbeat by heartbeat' damage that accumulates from early mid-life; and that it is when that reserve is exhausted, typically in late age, that symptoms of organ failure emerge and progress. If this common cause can be established, a step will have been taken towards the understanding, treatment and delay of three conditions that have their beginnings in every individual and that, in those who survive other causes of death, become lethal in late age. |
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AbstractList | This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosis have a common cause in pulse-induced capillary haemorrhage. All three conditions are age-related and characterised by insidious onset, uncertainty about their cause, exacerbation by hypertension, resistance to treatment and the relentlessness of their progression. We argue that the three conditions are the clinical outcomes of damage caused by pulse-induced haemorrhage from capillaries. The damage, first detectable in mid-life, creates first mild and then severe symptoms of cognitive, renal and pulmonary dysfunction. We also review evidence that in all three organs there has developed, by young adulthood, a reserve of tissue that enables them to function well, despite the 'heartbeat by heartbeat' damage that accumulates from early mid-life; and that it is when that reserve is exhausted, typically in late age, that symptoms of organ failure emerge and progress. If this common cause can be established, a step will have been taken towards the understanding, treatment and delay of three conditions that have their beginnings in every individual and that, in those who survive other causes of death, become lethal in late age. This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosis have a common cause in pulse-induced capillary haemorrhage. All three conditions are age-related and characterised by insidious onset, uncertainty about their cause, exacerbation by hypertension, resistance to treatment and the relentlessness of their progression. We argue that the three conditions are the clinical outcomes of damage caused by pulse-induced haemorrhage from capillaries. The damage, first detectable in mid-life, creates first mild and then severe symptoms of cognitive, renal and pulmonary dysfunction. We also review evidence that in all three organs there has developed, by young adulthood, a reserve of tissue that enables them to function well, despite the 'heartbeat by heartbeat' damage that accumulates from early mid-life; and that it is when that reserve is exhausted, typically in late age, that symptoms of organ failure emerge and progress. If this common cause can be established, a step will have been taken towards the understanding, treatment and delay of three conditions that have their beginnings in every individual and that, in those who survive other causes of death, become lethal in late age.This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosis have a common cause in pulse-induced capillary haemorrhage. All three conditions are age-related and characterised by insidious onset, uncertainty about their cause, exacerbation by hypertension, resistance to treatment and the relentlessness of their progression. We argue that the three conditions are the clinical outcomes of damage caused by pulse-induced haemorrhage from capillaries. The damage, first detectable in mid-life, creates first mild and then severe symptoms of cognitive, renal and pulmonary dysfunction. We also review evidence that in all three organs there has developed, by young adulthood, a reserve of tissue that enables them to function well, despite the 'heartbeat by heartbeat' damage that accumulates from early mid-life; and that it is when that reserve is exhausted, typically in late age, that symptoms of organ failure emerge and progress. If this common cause can be established, a step will have been taken towards the understanding, treatment and delay of three conditions that have their beginnings in every individual and that, in those who survive other causes of death, become lethal in late age. |
Audience | Academic |
Author | Robinson, Stephen R Mitrofanis, John Johnstone, Daniel M Stone, Jonathan |
AuthorAffiliation | 2 School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia; stephen.robinson@rmit.edu.au 3 Fonds de Dotation, Clinatec, Université Grenoble Alpes, 38000 Grenoble, France; john.mitrofanis@univ-grenoble-alpes.fr 4 School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia; daniel.johnstone@newcastle.edu.au 1 Discipline of Physiology, and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia |
AuthorAffiliation_xml | – name: 2 School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia; stephen.robinson@rmit.edu.au – name: 3 Fonds de Dotation, Clinatec, Université Grenoble Alpes, 38000 Grenoble, France; john.mitrofanis@univ-grenoble-alpes.fr – name: 1 Discipline of Physiology, and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia – name: 4 School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia; daniel.johnstone@newcastle.edu.au |
Author_xml | – sequence: 1 givenname: Jonathan surname: Stone fullname: Stone, Jonathan organization: Discipline of Physiology, and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia – sequence: 2 givenname: Stephen R orcidid: 0000-0002-0987-0075 surname: Robinson fullname: Robinson, Stephen R organization: School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia – sequence: 3 givenname: John surname: Mitrofanis fullname: Mitrofanis, John organization: Fonds de Dotation, Clinatec, Université Grenoble Alpes, 38000 Grenoble, France – sequence: 4 givenname: Daniel M surname: Johnstone fullname: Johnstone, Daniel M organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia |
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Keywords | capillary haemorrhage dementia chronic kidney disease idiopathic pulmonary fibrosis hypertension healthy ageing |
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SubjectTerms | Aging Blood vessels Brain Brain damage Capillaries capillary haemorrhage chronic kidney disease Chronic kidney failure Dementia Dementia disorders Development and progression Failure Fibrosis healthy ageing Hemorrhage Hypertension idiopathic pulmonary fibrosis Kidney diseases Lung diseases Lungs Medical treatment Middle age Neuropathology Pathology Proteins Pulmonary fibrosis Renal failure Renal function Review |
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Title | A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse? |
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