Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects

• Published in: The European respiratory journal Vol. 28; no. 3; pp. 513 - 522
• Main Authors: Muller, M, Grunewald, J, Olgart Hoglund, C, Dahlen, B, Eklund, A, Stridh, H
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.09.2006; Maney
• Subjects: Adult; Allergens - administration & dosage; Allergens - immunology; Apoptosis; Asthma - immunology; Biological and medical sciences; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid - cytology; Caspase 3 - analysis; Chronic obstructive pulmonary disease, asthma; Female; Humans; Hypersensitivity, Immediate - immunology; Lung - immunology; Lymphocytes - immunology; Male; Medical sciences; Middle Aged; Pneumology; Proto-Oncogene Proteins c-bcl-2 - analysis; Trialkyltin Compounds - toxicity; Human; Immunopathology; Lung disease; Allergy; lymphocytes; Respiratory disease; Enzyme; Caspase; Exposure; Asthma; Atopy; Peptidases; tributyltin; Bronchoalveolar lavage; Bronchus disease; Hydrolases; Obstructive pulmonary disease; Lymphocyte; caspases; Allergen; Apoptosis

The increased number of lymphocytes in airways during an asthmatic response is believed to be the result of increased recruitment of these cells. However, it is possible that a decreased apoptotic rate could also contribute to the increased number. The aim of the present study was to investigate whe...