Effect of actual long-term spaceflight on BDNF, TrkB, p75, BAX and BCL-XL genes expression in mouse brain regions

• Published in: Neuroscience Vol. 284; pp. 730 - 736
• Main Authors: Naumenko, V.S, Kulikov, A.V, Kondaurova, E.M, Tsybko, A.S, Kulikova, E.A, Krasnov, I.B, Shenkman, B.S, Sychev, V.N, Bazhenova, E.Y, Sinyakova, N.A, Popova, N.K
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 22.01.2015
• Subjects: Animals; BAX, BCL-XL, BDNF, TrkB, p75 genes expression; bcl-2-Associated X Protein - metabolism; bcl-X Protein - metabolism; Brain - metabolism; Brain-Derived Neurotrophic Factor - metabolism; environmental stress; Gene Expression; Housing, Animal; Male; mice; Mice, Inbred C57BL; microgravity; Neurology; Receptor, trkB - metabolism; Receptors, Nerve Growth Factor - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Space Flight; spaceflight; Stress, Physiological - physiology; spaceflight; microgravity; rPol II; environmental stress; BDNF; BAX, BCL-X L, BDNF, TrkB, p75 genes expression; DNA-dependent RNA polymerase II; brain-derived neurotrophic factor; mice; PCR; polymerase chain reaction; BAX, BCL-XL, BDNF, TrkB, p75 genes expression; BAX, BCL-X(L), BDNF, TrkB, p75 genes expression
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.10.045

Highlights • Actual spaceflight considerably decreased BCL-XL gene expression in the hypothalamus. • Long-term spaceflight significantly increased BCL-XL gene expression in the hippocampus. • Actual spaceflight considerably reduced BCL-XL gene expression in the striatum. • Shuttle cabin housing also considerably reduced BCL-XL gene expression in the striatum. • Long-term spaceflight failed to affect BAX, BDNF, TrkB and p75 gene expression.