Ampelopsin Suppresses Stem Cell Properties Accompanied by Attenuation of Oxidative Phosphorylation in Chemo- and Radio-Resistant MDA-MB-231 Breast Cancer Cells

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 8; p. 794
• Main Authors: Truong, Vi Nguyen-Phuong, Nguyen, Yen Thi-Kim, Cho, Somi-Kim
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 12.08.2021; MDPI
• Subjects: ampelopsin; Apoptosis; Breast cancer; cancer stem cells; Cancer therapies; Cytotoxicity; Flavonoids; Herbal medicine; Kinases; medicinal plants; Metabolism; Metastasis; NF-κB signaling; Phosphorylation; Phytochemicals; resistance; Stem cells; Tumor necrosis factor-TNF; Tumors

Ampelopsin, also known as dihydromyricetin, is a commonly found flavonoid in medicinal plants. The cancer stem cell (CSC) population is a promising target for triple-negative breast cancer (TNBC). In this study, flavonoid screening was performed in the established MDA-MB-231/IR cell line, which is e...