MicroRNAs from urinary extracellular vesicles are non-invasive early biomarkers of diabetic nephropathy in type 2 diabetes patients with the ‘Asian Indian phenotype’

• Published in: Diabetes & metabolism Vol. 45; no. 3; pp. 276 - 285
• Main Authors: Prabu, P., Rome, S., Sathishkumar, C., Gastebois, C., Meugnier, E., Mohan, V., Balasubramanyam, M.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.06.2019; Elsevier Masson
• Subjects: Adult; Albuminuria - diagnosis; Albuminuria - urine; Asian Continental Ancestry Group; Biomarkers - urine; Diabetes; Diabetes Mellitus, Type 2 - urine; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - urine; Extracellular vesicles; Extracellular Vesicles - metabolism; Female; Humans; Life Sciences; Male; Microalbumin; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; MiRNA; Nephropathy; Phenotype; Urinary; Extracellular vesicles; Microalbumin; Nephropathy; Urinary; Diabetes; MiRNA

MicroRNAs (miRNAs) from extracellular vesicles (EVs) have been proposed as promising biomarkers for a number of diseases. In this study, their potential as urine-based biomarkers of diabetic nephropathy (DN) was assessed. MiRNAs were profiled in urinary EVs from 160 fasting subjects with normal gluc...