The origin and development of nonlymphoid tissue CD103+ DCs

• Published in: The Journal of experimental medicine Vol. 206; no. 13; pp. 3115 - 3130
• Main Authors: Ginhoux, Florent, Liu, Kang, Helft, Julie, Bogunovic, Milena, Greter, Melanie, Hashimoto, Daigo, Price, Jeremy, Yin, Na, Bromberg, Jonathan, Lira, Sergio A., Stanley, E. Richard, Nussenzweig, Michel, Merad, Miriam
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 21.12.2009
• Subjects: Animals; Antigens, CD - analysis; CD11b Antigen - analysis; CD8 Antigens - analysis; Cell Differentiation; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - physiology; fms-Like Tyrosine Kinase 3 - analysis; fms-Like Tyrosine Kinase 3 - physiology; Homeostasis; Inhibitor of Differentiation Protein 2 - physiology; Integrin alpha Chains - analysis; Interferon Regulatory Factors - physiology; Male; Mice; Mice, Inbred C57BL; Receptor, Macrophage Colony-Stimulating Factor - analysis; Receptor, Macrophage Colony-Stimulating Factor - physiology; Stem Cells - physiology

CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 an...