The origin and development of nonlymphoid tissue CD103+ DCs
CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 an...
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| Published in | The Journal of experimental medicine Vol. 206; no. 13; pp. 3115 - 3130 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The Rockefeller University Press
21.12.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c+MHCII+ cells in tissues, which is CD103−CD11b+, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8+ DCs derive from the same precursor and follow a related differentiation program. |
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| AbstractList | CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c+MHCII+ cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103+ DCs are related to lymphoid organ CD8+ DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103+ DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c+MHCII+ cells in tissues, which is CD103−CD11b+, is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103+ DCs and lymphoid organ CD8+ DCs derive from the same precursor and follow a related differentiation program. CD103 + dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c + MHCII + cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103 + DCs are related to lymphoid organ CD8 + DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103 + DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c + MHCII + cells in tissues, which is CD103 − CD11b + , is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103 + DCs and lymphoid organ CD8 + DCs derive from the same precursor and follow a related differentiation program. CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c(+)MHCII(+) cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103(+) DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103(+) DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c(+)MHCII(+) cells in tissues, which is CD103(-)CD11b(+), is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program. CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c(+)MHCII(+) cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103(+) DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103(+) DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c(+)MHCII(+) cells in tissues, which is CD103(-)CD11b(+), is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program.CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the mechanisms that regulate the development of these cells. We show that two populations of CD11c(+)MHCII(+) cells separated on the basis of CD103 and CD11b expression coexist in most nonlymphoid tissues with the exception of the lamina propria. CD103(+) DCs are related to lymphoid organ CD8(+) DCs in that they are derived exclusively from pre-DCs under the control of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103(+) DCs express CD11b and develop independently of Id2 and IRF8. The other population of CD11c(+)MHCII(+) cells in tissues, which is CD103(-)CD11b(+), is heterogenous and depends on both Flt3 and MCSF-R. Our results reveal that nonlymphoid tissue CD103(+) DCs and lymphoid organ CD8(+) DCs derive from the same precursor and follow a related differentiation program. |
| Author | Lira, Sergio A. Stanley, E. Richard Bromberg, Jonathan Bogunovic, Milena Hashimoto, Daigo Price, Jeremy Merad, Miriam Ginhoux, Florent Nussenzweig, Michel Liu, Kang Helft, Julie Greter, Melanie Yin, Na |
| AuthorAffiliation | 4 Laboratory of Molecular Immunology and 5 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 3 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore 6 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461 1 Department of Gene and Cell Medicine and 2 the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 |
| AuthorAffiliation_xml | – name: 6 Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461 – name: 4 Laboratory of Molecular Immunology and 5 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065 – name: 1 Department of Gene and Cell Medicine and 2 the Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029 – name: 3 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore |
| Author_xml | – sequence: 1 givenname: Florent surname: Ginhoux fullname: Ginhoux, Florent – sequence: 2 givenname: Kang surname: Liu fullname: Liu, Kang – sequence: 3 givenname: Julie surname: Helft fullname: Helft, Julie – sequence: 4 givenname: Milena surname: Bogunovic fullname: Bogunovic, Milena – sequence: 5 givenname: Melanie surname: Greter fullname: Greter, Melanie – sequence: 6 givenname: Daigo surname: Hashimoto fullname: Hashimoto, Daigo – sequence: 7 givenname: Jeremy surname: Price fullname: Price, Jeremy – sequence: 8 givenname: Na surname: Yin fullname: Yin, Na – sequence: 9 givenname: Jonathan surname: Bromberg fullname: Bromberg, Jonathan – sequence: 10 givenname: Sergio A. surname: Lira fullname: Lira, Sergio A. – sequence: 11 givenname: E. Richard surname: Stanley fullname: Stanley, E. Richard – sequence: 12 givenname: Michel surname: Nussenzweig fullname: Nussenzweig, Michel – sequence: 13 givenname: Miriam surname: Merad fullname: Merad, Miriam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20008528$$D View this record in MEDLINE/PubMed |
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| Snippet | CD103+ dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the... CD103(+) dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the... CD103 + dendritic cells (DCs) in nonlymphoid tissues are specialized in the cross-presentation of cell-associated antigens. However, little is known about the... |
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| SubjectTerms | Animals Antigens, CD - analysis CD11b Antigen - analysis CD8 Antigens - analysis Cell Differentiation Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - physiology fms-Like Tyrosine Kinase 3 - analysis fms-Like Tyrosine Kinase 3 - physiology Homeostasis Inhibitor of Differentiation Protein 2 - physiology Integrin alpha Chains - analysis Interferon Regulatory Factors - physiology Male Mice Mice, Inbred C57BL Receptor, Macrophage Colony-Stimulating Factor - analysis Receptor, Macrophage Colony-Stimulating Factor - physiology Stem Cells - physiology |
| Title | The origin and development of nonlymphoid tissue CD103+ DCs |
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