EFFECTS OF SODIUM DIETHYLDITHIOCARBAMATE ON TYPE II PULMONARY EPITHELIAL CELLS IN VITRO

• Published in: Journal of Toxicology and Environmental Health, Part A Vol. 62; no. 3; pp. 207 - 216
• Main Authors: Tátrai, Erzsébet, Kováciková, Zuzana, Karácsony, Géza, Hudák, Aranka, Adamis, Zoltán, Ungváry, György
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 09.02.2001
• Subjects: Acetylgalactosamine - metabolism; Alkaline Phosphatase - metabolism; Animals; Cell Membrane - drug effects; Cell Membrane - metabolism; Cell Survival - drug effects; Cells, Cultured; Ditiocarb - toxicity; Dose-Response Relationship, Drug; Galactose - metabolism; gamma-Glutamyltransferase - metabolism; Glutathione Peroxidase - metabolism; Glutathione Reductase - metabolism; Histocytochemistry; Lectins - metabolism; Male; Plant Lectins; Pulmonary Alveoli - cytology; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - enzymology; Rats; Rats, Sprague-Dawley; Superoxide Dismutase - metabolism; Trypan Blue

Dithiocarbamates (DDTC) are chemicals widely used in the form of pesticides, therapeutic and chelating agents, and scavengers. Since DDTC interfere with SH, Cu, and Zn enzymes due to chelating properties, it was of interest to clarify, in primary culture of type II alveolar pneumocytes, the effect o...