Indomethacin restores loss of hippocampal neurogenesis and cholinergic innervation and reduces innate immune expression and reversal learning deficits in adult male and female rats following adolescent ethanol exposure

• Published in: Alcohol, clinical & experimental research Vol. 47; no. 3; pp. 470 - 485
• Main Authors: Macht, Victoria, Vetreno, Ryan, Elchert, Natalie, Fisher, Rachael, Crews, Fulton
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2023
• Subjects: acetylcholine; Acetyltransferase; alcohol; Animal memory; Animals; Basal forebrain; Choline O-acetyltransferase; Cholinergic Agents - metabolism; Cholinergic Agents - pharmacology; Cholinergic Neurons - metabolism; Cholinergic Neurons - pathology; cognitive flexibility; doublecortin; Doublecortin protein; Ethanol; Ethanol - pharmacology; Female; Females; Forebrain; Hippocampus; HMGB1 protein; Immunity, Innate; Immunoreactivity; Indomethacin; Indomethacin - metabolism; Indomethacin - pharmacology; Inflammation; Innervation; Male; Males; Maze Learning; Neurogenesis; neuroinflammation; Prosencephalon; Prostaglandin endoperoxide synthase; Rats; Reversal Learning; Rodents; Spatial discrimination learning; Teenagers; Vesicular acetylcholine transporter; alcohol; doublecortin; acetylcholine; cognitive flexibility; neuroinflammation

Background Adolescent intermittent ethanol (AIE) exposure causes long‐term changes in the brain and behavior of adult male rodents, including persistent induction of innate immune pathways, reductions in hippocampal neurogenic and forebrain cholinergic neuronal markers, and reversal learning deficit...