Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes

• Published in: Critical care medicine Vol. 45; no. 1; p. 58
• Main Authors: Dalli, Jesmond, Colas, Romain A, Quintana, Carolina, Barragan-Bradford, Diana, Hurwitz, Shelley, Levy, Bruce D, Choi, Augustine M, Serhan, Charles N, Baron, Rebecca M
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Adult; Aged; Aged, 80 and over; Bicarbonates - blood; Bilirubin - blood; Blood Gas Analysis; Cytokines - blood; Discriminant Analysis; Docosahexaenoic Acids - blood; Eicosanoids - blood; Female; Glasgow Coma Scale; Humans; Intensive Care Units; Male; Massachusetts - epidemiology; Middle Aged; Partial Thromboplastin Time; Respiration, Artificial - statistics & numerical data; Respiratory Distress Syndrome, Adult - blood; Respiratory Distress Syndrome, Adult - etiology; Respiratory Insufficiency - mortality; Sepsis - blood; Sepsis - mortality; Vasoconstrictor Agents - therapeutic use

To identify and measure recently described chemical mediators, termed specialized pro-resolving mediators that actively regulate the resolution of acute-inflammation, and correlate measurements with clinical outcomes. Herein, deidentified plasma was collected from sepsis patients (n = 22 subjects) w...