Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report

Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoint...

Full description

Saved in:
Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 1523; no. 1; pp. 38 - 50
Main Authors Cable, Jennifer, Rathmell, Jeffrey C., Pearce, Erika L., Ho, Ping‐Chih, Haigis, Marcia C., Mamedov, Murad R., Wu, Meng‐Ju, Kaech, Susan M., Lynch, Lydia, Febbraio, Mark A., Bapat, Sagar P., Hong, Hanna S., Zou, Weiping, Belkaid, Yasmine, Sullivan, Zuri A., Keller, Andrea, Wculek, Stefanie K., Green, Douglas R., Postic, Catherine, Amit, Ido, Benitah, Salvador Aznar, Jones, Russell G., Reina‐Campos, Miguel, Torres, Santiago Valle, Beyaz, Semir, Brennan, Donal, O'Neill, Luke A. J., Perry, Rachel J., Brenner, Dirk
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.05.2023
Subjects
Cancer
Humans
Immune System
Immunity
immunometabolism
immunotherapy
Metabolic Networks and Pathways
Metabolic pathways
Metabolism
Microbiomes
Neoplasms - metabolism
New technology
Obesity
Obesity - metabolism
Obesity - therapy
Pathogenesis
Therapeutic targets
Tumor cells
Tumor Microenvironment
Tumors
cancer
metabolism
immunity
immunometabolism
obesity
immunotherapy
Online AccessGet full text

Cover

Abstract Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5–8, 2022, experts in the field of immunometabolism met for the Keystone symposium “Immunometabolism at the Crossroads of Obesity and Cancer” to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity. Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. This report presents recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer.
AbstractList Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5–8, 2022, experts in the field of immunometabolism met for the Keystone symposium “Immunometabolism at the Crossroads of Obesity and Cancer” to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity. Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. This report presents recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer.
Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5–8, 2022, experts in the field of immunometabolism met for the Keystone symposium “Immunometabolism at the Crossroads of Obesity and Cancer” to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.
Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5–8, 2022, experts in the field of immunometabolism met for the Keystone symposium “Immunometabolism at the Crossroads of Obesity and Cancer” to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the TME as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity. Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. On September 5–8, 2022, experts in the field of immunometabolism met for the Keystone symposium “Immunometabolism at the Crossroads of Obesity and Cancer” to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer.
Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5-8, 2022, experts in the field of immunometabolism met for the Keystone symposium "Immunometabolism at the Crossroads of Obesity and Cancer" to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.
Author Haigis, Marcia C.
Kaech, Susan M.
Brennan, Donal
Torres, Santiago Valle
Beyaz, Semir
Jones, Russell G.
Rathmell, Jeffrey C.
Postic, Catherine
Zou, Weiping
Wculek, Stefanie K.
Pearce, Erika L.
Mamedov, Murad R.
Amit, Ido
Benitah, Salvador Aznar
Ho, Ping‐Chih
Brenner, Dirk
Lynch, Lydia
Belkaid, Yasmine
Febbraio, Mark A.
Reina‐Campos, Miguel
Sullivan, Zuri A.
Perry, Rachel J.
Green, Douglas R.
Cable, Jennifer
Hong, Hanna S.
Bapat, Sagar P.
O'Neill, Luke A. J.
Wu, Meng‐Ju
Keller, Andrea
AuthorAffiliation 16 Department of Biological Chemistry and Pharmacology, College of Medicine; and Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, Ohio
23 University of California, San Diego, La Jolla, California
18 St. Jude Children’s Research Hospital, Memphis, Tennessee
3 Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
6 Gladstone-UCSF Institute of Genomic Immunology and Department of Medicine, University of California San Francisco, San Francisco, California
12 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan
8 NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California
2 Vanderbilt-Ingram Cancer Center; Vanderbilt Center for Immunobiology; Department of Pathology, Microbiology, and Immunology, Vanderbilt Univers
AuthorAffiliation_xml – name: 3 Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland and Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
– name: 26 UCD Gynecological Oncology Group, UCD School of Medicine, Catherine McAuley Research Centre, Mater Misericordiae University Hospital, Belfield, Dublin, Ireland
– name: 16 Department of Biological Chemistry and Pharmacology, College of Medicine; and Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, The Ohio State University, Columbus, Ohio
– name: 13 Department of Surgery; Center of Excellence for Cancer Immunology and Immunotherapy, University of Michigan Rogel Cancer Center; Department of Pathology; Graduate Program in Immunology; Graduate Program in Cancer Biology, University of Michigan School of Medicine, Ann Arbor, Michigan
– name: 15 Department of Immunobiology, Molecular and Cellular Biology, Harvard University, Cambridge, MA
– name: 29 Experimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Immunology and Genetics, Luxembourg Centre for System Biomedicine (LCSB), University of Luxembourg, Belval, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark
– name: 24 Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia
– name: 18 St. Jude Children’s Research Hospital, Memphis, Tennessee
– name: 20 Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel
– name: 2 Vanderbilt-Ingram Cancer Center; Vanderbilt Center for Immunobiology; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center; Nashville, Tennessee
– name: 8 NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California
– name: 27 School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland
– name: 1 PhD Science Writer, New York, New York
– name: 9 Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
– name: 12 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan
– name: 19 Université Paris Cité, CNRS, INSERM, Institut Cochin, Paris, France
– name: 17 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Current address: Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain
– name: 6 Gladstone-UCSF Institute of Genomic Immunology and Department of Medicine, University of California San Francisco, San Francisco, California
– name: 11 Diabetes Center and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
– name: 25 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
– name: 21 Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST) and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
– name: 5 Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts
– name: 10 Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
– name: 4 Department of Fundamental Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland
– name: 14 Metaorganism Immunity Section, Laboratory of Immune System Biology, and NIAID Microbiome Program National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
– name: 22 Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, Michigan
– name: 23 University of California, San Diego, La Jolla, California
– name: 7 Cancer Center, Massachusetts General Hospital; Department of Medicine, Harvard Medical School, Boston; and Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts
– name: 28 Department of Cellular and Molecular Physiology and Department of Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, Connecticut
Author_xml – sequence: 1
  givenname: Jennifer
  surname: Cable
  fullname: Cable, Jennifer
  email: annals@nyas.org
  organization: PhD Science Writer
– sequence: 2
  givenname: Jeffrey C.
  surname: Rathmell
  fullname: Rathmell, Jeffrey C.
  organization: Vanderbilt University Medical Center
– sequence: 3
  givenname: Erika L.
  surname: Pearce
  fullname: Pearce, Erika L.
  organization: Max Planck Institute of Immunobiology and Epigenetics
– sequence: 4
  givenname: Ping‐Chih
  surname: Ho
  fullname: Ho, Ping‐Chih
  organization: University of Lausanne
– sequence: 5
  givenname: Marcia C.
  surname: Haigis
  fullname: Haigis, Marcia C.
  organization: Harvard Medical School
– sequence: 6
  givenname: Murad R.
  surname: Mamedov
  fullname: Mamedov, Murad R.
  organization: University of California San Francisco
– sequence: 7
  givenname: Meng‐Ju
  surname: Wu
  fullname: Wu, Meng‐Ju
  organization: Broad Institute of Harvard and Massachusetts Institute of Technology
– sequence: 8
  givenname: Susan M.
  surname: Kaech
  fullname: Kaech, Susan M.
  organization: Salk Institute for Biological Studies
– sequence: 9
  givenname: Lydia
  surname: Lynch
  fullname: Lynch, Lydia
  organization: Harvard Medical School
– sequence: 10
  givenname: Mark A.
  surname: Febbraio
  fullname: Febbraio, Mark A.
  organization: Monash University
– sequence: 11
  givenname: Sagar P.
  surname: Bapat
  fullname: Bapat, Sagar P.
  organization: University of California San Francisco
– sequence: 12
  givenname: Hanna S.
  surname: Hong
  fullname: Hong, Hanna S.
  organization: University of Michigan
– sequence: 13
  givenname: Weiping
  surname: Zou
  fullname: Zou, Weiping
  organization: University of Michigan School of Medicine
– sequence: 14
  givenname: Yasmine
  surname: Belkaid
  fullname: Belkaid, Yasmine
  organization: National Institutes of Health
– sequence: 15
  givenname: Zuri A.
  surname: Sullivan
  fullname: Sullivan, Zuri A.
  organization: Harvard University
– sequence: 16
  givenname: Andrea
  surname: Keller
  fullname: Keller, Andrea
  organization: The Ohio State University
– sequence: 17
  givenname: Stefanie K.
  surname: Wculek
  fullname: Wculek, Stefanie K.
  organization: Centro Nacional de Investigaciones Cardiovasculares (CNIC)
– sequence: 18
  givenname: Douglas R.
  surname: Green
  fullname: Green, Douglas R.
  organization: St. Jude Children's Research Hospital
– sequence: 19
  givenname: Catherine
  surname: Postic
  fullname: Postic, Catherine
  organization: Université Paris Cité, CNRS, INSERM, Institut Cochin
– sequence: 20
  givenname: Ido
  surname: Amit
  fullname: Amit, Ido
  organization: Weizmann Institute of Science
– sequence: 21
  givenname: Salvador Aznar
  surname: Benitah
  fullname: Benitah, Salvador Aznar
  organization: The Barcelona Institute of Science and Technology (BIST) and Catalan Institution for Research and Advanced Studies (ICREA)
– sequence: 22
  givenname: Russell G.
  surname: Jones
  fullname: Jones, Russell G.
  organization: Van Andel Research Institute
– sequence: 23
  givenname: Miguel
  surname: Reina‐Campos
  fullname: Reina‐Campos, Miguel
  organization: San Diego
– sequence: 24
  givenname: Santiago Valle
  surname: Torres
  fullname: Torres, Santiago Valle
  organization: University of Melbourne
– sequence: 25
  givenname: Semir
  surname: Beyaz
  fullname: Beyaz, Semir
  organization: Cold Spring Harbor Laboratory
– sequence: 26
  givenname: Donal
  surname: Brennan
  fullname: Brennan, Donal
  organization: Mater Misericordiae University Hospital
– sequence: 27
  givenname: Luke A. J.
  surname: O'Neill
  fullname: O'Neill, Luke A. J.
  organization: Trinity Biomedical Sciences Institute, Trinity College
– sequence: 28
  givenname: Rachel J.
  surname: Perry
  fullname: Perry, Rachel J.
  organization: Yale University School of Medicine
– sequence: 29
  givenname: Dirk
  surname: Brenner
  fullname: Brenner, Dirk
  organization: University of Southern Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36960914$$D View this record in MEDLINE/PubMed
BookMark eNp9kctu1TAYhC1URE8LGx4AWWJTIaX4dux4haqKS0UFi9IFK8tJ_lBXiX2wHVB2PARPyJPgkBZBhfDGC38zGs8coD0fPCD0mJJjWs5zP9t0TIVW8h7aUCV0JSVne2hDiFJVrRnfRwcpXRNCWS3UA7TPpZZEU7FBl2fjOPkwQrZNGFwasc04XwFuY0gpBtslHHocGkguz9j6DrfWtxB_fPtu8VuYUy5h8MU87kJyFkfYhZgfovu9HRI8urkP0eWrlx9O31Tn71-fnZ6cV60QWlaKEyq7rtVWNUQR0rec1jUXvGTrBCi1ZX0je6CaCWCaaiHtllKigfQ1abb8EL1YfXdTM0LXgs_RDmYX3WjjbIJ15u8X767Mp_DFUMKl4nRxOLpxiOHzBCmb0aUWhsF6CFMyTGlaUKVEQZ_eQa_DFH35n2E1ZaXTmizUkz8j_c5yW3kByAqsDUNvWpdtdmFJ6IYSzSyrmmVV82vVInl2R3Lr-k-YrvBXN8D8H9K8-3hysWp-ArbIs74
CitedBy_id crossref_primary_10_46235_1028_7221_16616_AOS
crossref_primary_10_1007_s11695_024_07598_3
crossref_primary_10_29219_fnr_v68_10545
Cites_doi 10.1158/2326-6066.CIR-20-0384
10.1016/j.cmet.2021.09.004
10.1083/jcb.201501101
10.1016/j.eclinm.2021.101213
10.1038/nature24302
10.1038/s43018-022-00338-5
10.1101/gad.191056.112
10.1126/science.aay5516
10.1038/s41586-019-1601-9
10.2337/db10-0452
10.1016/j.celrep.2017.09.065
10.1016/j.ygyno.2021.01.029
10.1158/2159-8290.CD-21-1077
10.3389/fimmu.2018.02826
10.1038/s42003-022-03422-9
10.1038/s41467-018-04361-y
10.1038/s41590-018-0251-7
10.3389/fphar.2022.982424
10.1371/journal.pone.0218126
10.1016/j.cell.2015.08.016
10.1038/s41568-019-0198-5
10.1038/s41586-021-04049-2
10.1172/JCI120803
10.1016/j.jhepr.2021.100346
10.1016/j.ccell.2020.09.004
10.4049/jimmunol.2001152
10.1038/s42255-020-00317-z
10.1172/JCI41636
10.1093/jncics/pkaa007
10.1016/j.immuni.2019.09.003
10.1001/jamaoncol.2019.5241
10.1200/JCO.2016.67.9712
10.1038/s41586-022-04536-0
10.1038/nature18629
10.1038/nature20791
10.1007/s10875-019-00737-x
10.1038/s41577-021-00537-8
10.3389/fimmu.2022.915837
10.1073/pnas.1804149115
10.1016/j.cmet.2016.06.007
10.1016/S1470-2045(18)30078-0
10.1016/j.stem.2021.08.007
10.1038/s41591-021-01232-w
10.4049/jimmunol.1600810
10.1038/s41586-020-2040-3
10.1038/s42255-018-0014-7
10.1016/j.immuni.2020.01.006
10.1016/j.ccr.2014.07.001
10.1038/s41587-020-0442-2
10.1038/s41577-019-0162-3
10.1172/JCI96061
10.1126/science.1225152
10.1016/j.cell.2021.05.020
10.1038/s41591-018-0221-5
10.1016/j.cell.2017.12.033
10.1016/j.cell.2020.06.032
10.1016/j.ejca.2013.03.015
10.1002/hep.32424
10.1016/j.cmet.2022.06.008
10.1038/s41577-019-0124-9
10.1016/j.cmet.2017.01.016
10.1073/pnas.1708194114
10.1038/s41586-021-03478-3
10.1038/nature17173
10.3389/fchem.2021.669308
10.1084/jem.20210042
10.1016/j.cell.2022.03.011
10.1016/j.cmet.2022.07.012
10.1038/sj.ejhg.5201630
10.1038/s41586-022-04898-5
10.1038/s41422-020-0379-5
10.3389/fsurg.2022.943544
10.1038/nm863
10.1038/nature14052
10.1038/nature15514
10.1016/j.cmet.2022.09.023
10.1038/s42255-020-0261-2
10.1038/s41436-018-0022-8
10.1126/science.aba8310
10.1038/s41574-019-0230-6
10.1038/nature14228
10.1126/science.aat6280
10.1016/j.immuni.2017.03.019
10.1038/nature15541
10.1371/journal.pone.0029539
10.1016/j.cmet.2018.10.012
10.1016/j.cmet.2020.03.004
10.1126/science.aax6624
10.1038/s41586-021-04075-0
10.1038/s41596-021-00586-2
10.1038/s41590-021-01044-7
10.1016/j.cmet.2018.04.022
10.1016/j.stem.2021.03.001
ContentType Journal Article
Copyright 2023 New York Academy of Sciences.
2023 The New York Academy of Sciences.
Copyright_xml – notice: 2023 New York Academy of Sciences.
– notice: 2023 The New York Academy of Sciences.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QG
7QL
7QP
7QR
7ST
7T5
7T7
7TK
7TM
7TO
7U7
7U9
8FD
C1K
FR3
H94
K9.
M7N
P64
RC3
SOI
7X8
5PM
DOI 10.1111/nyas.14976
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Oncogenes and Growth Factors Abstracts
Technology Research Database
Toxicology Abstracts
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Genetics Abstracts
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Calcium & Calcified Tissue Abstracts
Environment Abstracts
MEDLINE - Academic
DatabaseTitleList
CrossRef

Virology and AIDS Abstracts
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Biology
EISSN 1749-6632
EndPage 50
ExternalDocumentID PMC10367315
36960914
10_1111_nyas_14976
NYAS14976
Genre article
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: National Institutes of Health
– fundername: NHLBI NIH HHS
  grantid: R38 HL143581
– fundername: NHLBI NIH HHS
  grantid: K38 HL154202
– fundername: NIDDK NIH HHS
  grantid: F30 DK096828
– fundername: NCATS NIH HHS
  grantid: UL1 TR001863
– fundername: NCI NIH HHS
  grantid: P30 CA045508
GroupedDBID ---
--Z
-~X
.3N
.55
.GA
.GJ
.Y3
05W
0R~
10A
1CY
1OB
1OC
23M
31~
33P
3O-
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5HH
5LA
5RE
5VS
66C
692
6J9
702
79B
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A03
AAESR
AAEVG
AAHHS
AAHQN
AAMDK
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABDBF
ABEML
ABJNI
ABLJU
ABPVW
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFO
ACGFS
ACIWK
ACPOU
ACPRK
ACRPL
ACSCC
ACUHS
ACXBN
ACXQS
ACYXJ
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEGXH
AEIGN
AEIMD
AELAQ
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFNX
AFFPM
AFGKR
AFPWT
AFRAH
AFSWV
AFWVQ
AFZJQ
AHBTC
AHEFC
AHMBA
AI.
AIAGR
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ATUGU
AUFTA
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BIYOS
BMNLL
BMXJE
BNHUX
BROTX
BRXPI
BY8
C45
CAG
CO8
COF
CS3
D-E
D-F
DC6
DCZOG
DPXWK
DR2
DRFUL
DRSTM
EBD
EBS
EJD
EMOBN
ESX
F00
F01
F04
F5P
FEDTE
FZ0
G-S
G.N
GODZA
H.T
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
I-F
IH2
IX1
J0M
K48
L7B
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NF~
NHB
O66
O9-
OHT
OIG
OK1
OVD
P2P
P2W
P2X
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
R.K
RAG
RIWAO
RJQFR
ROL
RX1
S10
SAMSI
SJN
SUPJJ
SV3
TEORI
TUS
UB1
UPT
V8K
VH1
W8V
W99
WBKPD
WH7
WHWMO
WIH
WIK
WOHZO
WQJ
WRC
WUP
WVDHM
WXSBR
X7M
XG1
YBU
YOC
YSK
ZGI
ZKB
ZXP
ZZTAW
~02
~IA
~KM
~WT
AAYXX
ADXHL
AEYWJ
AGHNM
AGQPQ
AGYGG
AHDLI
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
UMC
7QG
7QL
7QP
7QR
7ST
7T5
7T7
7TK
7TM
7TO
7U7
7U9
8FD
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
C1K
FR3
H94
K9.
M7N
P64
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-c4496-73016ddc9a7b0700fc3188343091d4e7752fb6fe1924e291946a51109e0f80b53
IEDL.DBID DR2
ISSN 0077-8923
1749-6632
IngestDate Thu Aug 21 18:34:33 EDT 2025
Fri Jul 11 16:24:10 EDT 2025
Fri Jul 25 10:29:39 EDT 2025
Mon May 05 07:04:40 EDT 2025
Tue Jul 01 04:00:57 EDT 2025
Thu Apr 24 23:05:59 EDT 2025
Wed Jan 22 16:21:24 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords cancer
metabolism
immunity
immunometabolism
obesity
immunotherapy
Language English
License 2023 New York Academy of Sciences.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4496-73016ddc9a7b0700fc3188343091d4e7752fb6fe1924e291946a51109e0f80b53
Notes Current address Stefanie K. Wculek, Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nyas.14976
PMID 36960914
PQID 2812369804
PQPubID 946344
PageCount 13
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10367315
proquest_miscellaneous_2791367774
proquest_journals_2812369804
pubmed_primary_36960914
crossref_citationtrail_10_1111_nyas_14976
crossref_primary_10_1111_nyas_14976
wiley_primary_10_1111_nyas_14976_NYAS14976
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate May 2023
PublicationDateYYYYMMDD 2023-05-01
PublicationDate_xml – month: 05
  year: 2023
  text: May 2023
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Annals of the New York Academy of Sciences
PublicationTitleAlternate Ann N Y Acad Sci
PublicationYear 2023
Publisher Wiley Subscription Services, Inc
Publisher_xml – name: Wiley Subscription Services, Inc
References 2021; 27
2021; 21
2012; 122
2019; 51
2021; 22
2018; 128
2011; 60
2021; 28
2021; 207
2019; 15
2017; 46
2019; 14
2014; 26
2019; 19
2019; 366
2021; 161
2020; 367
2017; 198
2017; 551
2022; 219
2017; 114
2016; 34
2019; 363
2018; 9
2020; 6
2020; 4
2020; 2
2021; 33
2018; 172
2020; 52
2021; 599
2019; 21
2021; 39
2019; 25
2003; 9
2022; 34
2019; 29
2020; 579
2021; 593
2022; 607
2022; 75
2012; 26
2022; 604
2012; 337
2015; 162
2021; 9
2018; 28
2021; 42
2021; 3
2013; 49
2017; 25
2020; 40
2015; 520
2019; 1
2017; 21
2020; 182
2006; 14
2020; 38
2021; 184
2015; 208
2015; 526
2011; 6
2018; 19
2021; 16
2022; 185
2022; 3
2020; 31
2022
2020; 30
2022; 5
2018; 115
2022; 9
2022; 12
2016; 531
2022; 13
2015; 519
2021; 371
2016; 535
2017; 541
2016; 24
2019; 574
e_1_2_9_75_1
e_1_2_9_31_1
e_1_2_9_52_1
e_1_2_9_50_1
e_1_2_9_73_1
e_1_2_9_79_1
e_1_2_9_94_1
e_1_2_9_10_1
e_1_2_9_35_1
e_1_2_9_56_1
e_1_2_9_77_1
e_1_2_9_12_1
e_1_2_9_33_1
e_1_2_9_54_1
e_1_2_9_90_1
e_1_2_9_92_1
e_1_2_9_71_1
e_1_2_9_14_1
e_1_2_9_39_1
e_1_2_9_16_1
e_1_2_9_37_1
e_1_2_9_58_1
e_1_2_9_18_1
e_1_2_9_41_1
e_1_2_9_64_1
e_1_2_9_87_1
e_1_2_9_20_1
e_1_2_9_62_1
e_1_2_9_89_1
e_1_2_9_22_1
e_1_2_9_45_1
e_1_2_9_68_1
e_1_2_9_83_1
e_1_2_9_24_1
e_1_2_9_43_1
e_1_2_9_66_1
e_1_2_9_85_1
e_1_2_9_8_1
e_1_2_9_6_1
e_1_2_9_81_1
e_1_2_9_4_1
e_1_2_9_60_1
e_1_2_9_2_1
e_1_2_9_26_1
e_1_2_9_49_1
e_1_2_9_28_1
e_1_2_9_47_1
e_1_2_9_30_1
e_1_2_9_53_1
e_1_2_9_74_1
e_1_2_9_51_1
e_1_2_9_72_1
e_1_2_9_11_1
e_1_2_9_34_1
e_1_2_9_57_1
e_1_2_9_78_1
e_1_2_9_95_1
e_1_2_9_13_1
e_1_2_9_32_1
e_1_2_9_55_1
e_1_2_9_76_1
e_1_2_9_91_1
e_1_2_9_93_1
e_1_2_9_70_1
e_1_2_9_15_1
e_1_2_9_38_1
e_1_2_9_17_1
e_1_2_9_36_1
e_1_2_9_59_1
e_1_2_9_19_1
e_1_2_9_42_1
e_1_2_9_63_1
e_1_2_9_88_1
e_1_2_9_40_1
e_1_2_9_61_1
e_1_2_9_21_1
e_1_2_9_46_1
e_1_2_9_67_1
e_1_2_9_84_1
e_1_2_9_23_1
e_1_2_9_44_1
e_1_2_9_65_1
e_1_2_9_86_1
e_1_2_9_7_1
e_1_2_9_80_1
e_1_2_9_5_1
e_1_2_9_82_1
e_1_2_9_3_1
e_1_2_9_9_1
e_1_2_9_25_1
e_1_2_9_27_1
e_1_2_9_48_1
e_1_2_9_69_1
e_1_2_9_29_1
References_xml – volume: 14
  start-page: 880
  year: 2006
  end-page: 883
  article-title: Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma
  publication-title: European Journal of Human Genetics
– volume: 2
  start-page: 1034
  year: 2020
  end-page: 1045
  article-title: Fructose stimulated de novo lipogenesis is promoted by inflammation
  publication-title: Nature Metabolism
– volume: 46
  start-page: 675
  year: 2017
  end-page: 689
  article-title: Glutathione primes T cell metabolism for inflammation
  publication-title: Immunity
– volume: 19
  start-page: 490
  year: 2019
  end-page: 502
  article-title: T cells and the skin: From protective immunity to inflammatory skin disorders
  publication-title: Nature Reviews Immunology
– volume: 184
  start-page: 3794
  year: 2021
  end-page: 3811.e19
  article-title: Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota
  publication-title: Cell
– volume: 49
  start-page: 2717
  year: 2013
  end-page: 2726
  article-title: Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer
  publication-title: European Journal of Cancer
– volume: 13
  year: 2022
  article-title: Recent advances of IDH1 mutant inhibitor in cancer therapy
  publication-title: Frontiers in Pharmacology
– volume: 162
  start-page: 1229
  year: 2015
  end-page: 1241
  article-title: Metabolic competition in the tumor microenvironment is a driver of cancer progression
  publication-title: Cell
– volume: 122
  start-page: 2176
  year: 2012
  end-page: 2194
  article-title: The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
  publication-title: Journal of Clinical Investigation
– volume: 337
  start-page: 1115
  year: 2012
  end-page: 1119
  article-title: Compartmentalized control of skin immunity by resident commensals
  publication-title: Science
– volume: 367
  year: 2020
  article-title: Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells
  publication-title: Science
– volume: 3
  issue: 6
  year: 2021
  article-title: New targets for NAFLD
  publication-title: JHEP Reports
– volume: 34
  start-page: 4277
  year: 2016
  end-page: 4283
  article-title: Obesity and cancer mechanisms: Cancer metabolism
  publication-title: Journal of Clinical Oncology
– volume: 1
  start-page: 16
  year: 2019
  end-page: 33
  article-title: Coupling Krebs cycle metabolites to signalling in immunity and cancer
  publication-title: Nature Metabolism
– volume: 60
  start-page: 1399
  year: 2011
  end-page: 1413
  article-title: O‐GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver
  publication-title: Diabetes
– volume: 30
  start-page: 649
  year: 2020
  end-page: 659
  article-title: Metabolic signaling in T cells
  publication-title: Cell Research
– volume: 51
  start-page: 856
  year: 2019
  end-page: 870.e5
  article-title: Metabolic profiling using stable isotope tracing reveals distinct patterns of glucose utilization by physiologically activated CD8 T cells
  publication-title: Immunity
– volume: 19
  start-page: 291
  year: 2019
  end-page: 304
  article-title: Immunometabolism at the interface between macrophages and pathogens
  publication-title: Nature Reviews Immunology
– volume: 24
  start-page: 104
  year: 2016
  end-page: 117
  article-title: Mitochondrial biogenesis and proteome remodeling promote one‐carbon metabolism for T cell activation
  publication-title: Cell Metabolism
– volume: 33
  start-page: 2316
  year: 2021
  end-page: 2328
  article-title: “Sweet death”: Fructose as a metabolic toxin that targets the gut–liver axis
  publication-title: Cell Metabolism
– volume: 172
  start-page: 784
  year: 2018
  end-page: 796.e18
  article-title: Non‐classical immunity controls microbiota impact on skin immunity and tissue repair
  publication-title: Cell
– volume: 25
  start-page: 141
  year: 2019
  end-page: 151
  article-title: Paradoxical effects of obesity on T cell function during tumor progression and PD‐1 checkpoint blockade
  publication-title: Nature Medicine
– volume: 12
  start-page: 812
  year: 2022
  end-page: 835
  article-title: Mutant IDH inhibits IFNγ‐TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
  publication-title: Cancer Discovery
– volume: 551
  start-page: 340
  year: 2017
  end-page: 345
  article-title: Inflammation‐induced IgA cells dismantle anti‐liver cancer immunity
  publication-title: Nature
– volume: 28
  start-page: 87
  year: 2018
  end-page: 103.e6
  article-title: Aerobic glycolysis controls myeloid‐derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple‐negative breast cancer
  publication-title: Cell Metabolism
– volume: 599
  start-page: 302
  year: 2021
  end-page: 307
  article-title: Low glycaemic diets alter lipid metabolism to influence tumour growth
  publication-title: Nature
– volume: 526
  start-page: 666
  year: 2015
  end-page: 671
  article-title: Caspase‐11 cleaves gasdermin D for non‐canonical inflammasome signalling
  publication-title: Nature
– volume: 114
  start-page: 10642
  year: 2017
  end-page: 10647
  article-title: Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 185
  start-page: 1373
  year: 2022
  end-page: 1388.e20
  article-title: LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma
  publication-title: Cell
– volume: 9
  year: 2021
  article-title: The emerging application of itaconate: Promising molecular targets and therapeutic opportunities
  publication-title: Frontiers in Chemistry
– volume: 4
  year: 2020
  article-title: The impact of obesity on tumor glucose uptake in breast and lung cancer
  publication-title: JNCI Cancer Spectrology
– year: 2022
– volume: 29
  start-page: 18
  year: 2019
  end-page: 26
  article-title: Preclinical models for studying NASH‐driven HCC: How useful are they?
  publication-title: Cell Metabolism
– volume: 535
  start-page: 153
  year: 2016
  end-page: 158
  article-title: Inflammasome‐activated gasdermin D causes pyroptosis by forming membrane pores
  publication-title: Nature
– volume: 371
  year: 2021
  article-title: γδ T cells regulate the intestinal response to nutrient sensing
  publication-title: Science
– volume: 22
  start-page: 1344
  year: 2021
  end-page: 1348
  article-title: Immune‐mediated inflammation across disease boundaries: Breaking down research silos
  publication-title: Nature Immunology
– volume: 28
  start-page: 598
  year: 2021
  end-page: 599
  article-title: High‐fat diet activates a PPAR‐δ program to enhance intestinal stem cell function
  publication-title: Cell Stem Cell
– volume: 128
  start-page: 580
  year: 2018
  end-page: 588
  article-title: PD‐L1 on host cells is essential for PD‐L1 blockade‐mediated tumor regression
  publication-title: Journal of Clinical Investigation
– volume: 363
  year: 2019
  article-title: Commensal‐specific T cell plasticity promotes rapid tissue adaptation to injury
  publication-title: Science
– volume: 26
  start-page: 1326
  year: 2012
  end-page: 1338
  article-title: Inhibition of α‐KG‐dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
  publication-title: Genes & Development
– volume: 161
  start-page: 143
  year: 2021
  end-page: 151
  article-title: Complete pathological response following levonorgestrel intrauterine device in clinically stage 1 endometrial adenocarcinoma: Results of a randomized clinical trial
  publication-title: Gynecologic Oncology
– volume: 531
  start-page: 53
  year: 2016
  end-page: 58
  article-title: High‐fat diet enhances stemness and tumorigenicity of intestinal progenitors
  publication-title: Nature
– volume: 34
  start-page: 1137
  year: 2022
  end-page: 1150.e6
  article-title: Tumor cells dictate anti‐tumor immune responses by altering pyruvate utilization and succinate signaling in CD8 T cells
  publication-title: Cell Metabolism
– volume: 42
  year: 2021
  article-title: Association of glucagon‐like peptide 1 analogs and agonists administered for obesity with weight loss and adverse events: A systematic review and network meta‐analysis
  publication-title: EClinicalMedicine
– volume: 574
  start-page: 63
  year: 2019
  end-page: 68
  article-title: Treatment of type 2 diabetes with the designer cytokine IC7Fc
  publication-title: Nature
– volume: 13
  year: 2022
  article-title: Gamma delta T‐cell based cancer immunotherapy: Past‐present‐future
  publication-title: Frontiers in Immunology
– volume: 541
  start-page: 41
  year: 2017
  end-page: 45
  article-title: Targeting metastasis‐initiating cells through the fatty acid receptor CD36
  publication-title: Nature
– volume: 366
  year: 2019
  article-title: MAIT cells are imprinted by the microbiota in early life and promote tissue repair
  publication-title: Science
– volume: 21
  start-page: 718
  year: 2021
  end-page: 738
  article-title: CD8 T cell metabolism in infection and cancer
  publication-title: Nature Reviews Immunology
– volume: 9
  start-page: 2826
  year: 2018
  article-title: Transcriptional and epigenetic regulation of effector and memory CD8 T cell differentiation
  publication-title: Frontiers in Immunology
– volume: 9
  start-page: 184
  year: 2021
  end-page: 199
  article-title: Pharmacologic screening identifies metabolic vulnerabilities of CD8 T cells
  publication-title: Cancer Immunology Research
– volume: 28
  start-page: 1922
  year: 2021
  end-page: 1935.e5
  article-title: Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
  publication-title: Cell Stem Cell
– volume: 519
  start-page: 57
  year: 2015
  end-page: 62
  article-title: A gp130‐Src‐YAP module links inflammation to epithelial regeneration
  publication-title: Nature
– volume: 128
  start-page: 1708
  year: 2018
  article-title: Host expression of PD‐L1 determines efficacy of PD‐L1 pathway blockade‐mediated tumor regression
  publication-title: Journal of Clinical Investigation
– volume: 19
  start-page: 1330
  year: 2018
  end-page: 1340
  article-title: Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
  publication-title: Nature Immunology
– volume: 115
  start-page: 13347
  year: 2018
  end-page: 13352
  article-title: Defective respiration and one‐carbon metabolism contribute to impaired naïve T cell activation in aged mice
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 3
  start-page: 21
  year: 2021
  end-page: 32
  article-title: Metabolites and the tumour microenvironment: From cellular mechanisms to systemic metabolism
  publication-title: Nature Metabolism
– volume: 26
  start-page: 331
  year: 2014
  end-page: 343
  article-title: ER stress cooperates with hypernutrition to trigger TNF‐dependent spontaneous HCC development
  publication-title: Cancer Cell
– volume: 6
  year: 2011
  article-title: The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes
  publication-title: PLoS ONE
– volume: 9
  start-page: 562
  year: 2003
  end-page: 567
  article-title: Blockade of B7‐H1 improves myeloid dendritic cell‐mediated antitumor immunity
  publication-title: Nature Medicine
– volume: 19
  start-page: 310
  year: 2018
  end-page: 322
  article-title: Association of body‐mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: A retrospective, multicohort analysis
  publication-title: Lancet Oncology
– volume: 34
  start-page: 1298
  year: 2022
  end-page: 1311.e6
  article-title: Carbon source availability drives nutrient utilization in CD8 T cells
  publication-title: Cell Metabolism
– volume: 3
  start-page: 303
  year: 2022
  end-page: 317
  article-title: The interaction of CD4 helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
  publication-title: Nature Cancer
– volume: 21
  start-page: 403
  year: 2017
  end-page: 416
  article-title: A specific ChREBP and PPARα cross‐talk is required for the glucose‐mediated FGF21 response
  publication-title: Cell Reports
– volume: 182
  start-page: 872
  year: 2020
  end-page: 885.e19
  article-title: Coupled scRNA‐seq and intracellular protein activity reveal an immunosuppressive role of TREM2 in cancer
  publication-title: Cell
– volume: 9
  year: 2022
  article-title: The role of bariatric and metabolic surgery in the development, diagnosis, and treatment of endometrial cancer
  publication-title: Frontiers in Surgery
– volume: 6
  start-page: 512
  year: 2020
  end-page: 518
  article-title: Association between body mass index and overall survival with immune checkpoint inhibitor therapy for advanced non‐small cell lung cancer
  publication-title: JAMA Oncology
– volume: 607
  start-page: 593
  year: 2022
  end-page: 603
  article-title: Mitochondrial RNA modifications shape metabolic plasticity in metastasis
  publication-title: Nature
– volume: 40
  start-page: 24
  year: 2020
  end-page: 64
  article-title: Human inborn errors of immunity: 2019 Update on the classification from the International Union of Immunological Societies Expert Committee
  publication-title: Journal of Clinical Immunology
– volume: 198
  start-page: 2735
  year: 2017
  end-page: 2746
  article-title: Inhibiting oxidative phosphorylation in vivo restrains Th17 effector responses and ameliorates murine colitis
  publication-title: Journal of Immunology
– volume: 15
  start-page: 507
  year: 2019
  end-page: 524
  article-title: The endocrine function of adipose tissues in health and cardiometabolic disease
  publication-title: Nature Reviews Endocrinology
– volume: 14
  year: 2019
  article-title: Obesity‐associated, but not obesity‐independent, tumors respond to insulin by increasing mitochondrial glucose oxidation
  publication-title: PLoS ONE
– volume: 25
  start-page: 228
  year: 2017
  end-page: 230
  article-title: Lipid metabolism fuels cancer's spread
  publication-title: Cell Metabolism
– volume: 604
  start-page: 337
  year: 2022
  end-page: 342
  article-title: Obesity alters pathology and treatment response in inflammatory disease
  publication-title: Nature
– volume: 31
  start-page: 920
  year: 2020
  end-page: 936.e7
  article-title: Glutathione restricts serine metabolism to preserve regulatory T cell function
  publication-title: Cell Metabolism
– volume: 75
  start-page: 1322
  year: 2022
  end-page: 1337
  article-title: Biology of IDH mutant cholangiocarcinoma
  publication-title: Hepatology
– volume: 219
  year: 2022
  article-title: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function
  publication-title: Journal of Experimental Medicine
– volume: 34
  start-page: 1675
  year: 2022
  end-page: 1699
  article-title: The role of lipids in cancer progression and metastasis
  publication-title: Cell Metabolism
– volume: 27
  start-page: 491
  year: 2021
  end-page: 503
  article-title: Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single‐cell sequencing
  publication-title: Nature Medicine
– volume: 520
  start-page: 104
  year: 2015
  end-page: 108
  article-title: Commensal–dendritic‐cell interaction specifies a unique protective skin immune signature
  publication-title: Nature
– volume: 5
  start-page: 478
  year: 2022
  article-title: A precision medicine approach to metabolic therapy for breast cancer in mice
  publication-title: Communications Biology
– volume: 9
  start-page: 2092
  year: 2018
  article-title: The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity
  publication-title: Nature Communications
– volume: 19
  start-page: 651
  year: 2019
  end-page: 661
  article-title: A framework for examining how diet impacts tumour metabolism
  publication-title: Nature Reviews Cancer
– volume: 38
  start-page: 629
  year: 2020
  end-page: 637
  article-title: Dissecting cellular crosstalk by sequencing physically interacting cells
  publication-title: Nature Biotechnology
– volume: 39
  start-page: 28
  year: 2021
  end-page: 37
  article-title: Immunometabolic interplay in the tumor microenvironment
  publication-title: Cancer Cell
– volume: 526
  start-page: 660
  year: 2015
  end-page: 665
  article-title: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
  publication-title: Nature
– volume: 593
  start-page: 607
  year: 2021
  end-page: 611
  article-title: Gasdermin D pore structure reveals preferential release of mature interleukin‐1
  publication-title: Nature
– volume: 579
  start-page: 581
  year: 2020
  end-page: 585
  article-title: Sex‐specific adipose tissue imprinting of regulatory T cells
  publication-title: Nature
– volume: 21
  start-page: 102
  year: 2019
  end-page: 106
  article-title: A proposed nosology of inborn errors of metabolism
  publication-title: Genetics in Medicine
– volume: 599
  start-page: 485
  year: 2021
  end-page: 490
  article-title: Dietary palmitic acid promotes a prometastatic memory via Schwann cells
  publication-title: Nature
– volume: 207
  start-page: 3122
  year: 2021
  end-page: 3130
  article-title: Leptin augments antitumor immunity in obesity by repolarizing tumor‐associated macrophages
  publication-title: Journal of Immunology
– volume: 52
  start-page: 328
  year: 2020
  end-page: 341.e5
  article-title: Febrile temperature critically controls the differentiation and pathogenicity of T helper 17 cells
  publication-title: Immunity
– volume: 208
  start-page: 869
  year: 2015
  end-page: 880
  article-title: A little sugar goes a long way: The cell biology of O‐GlcNAc
  publication-title: Journal of Cell Biology
– volume: 16
  start-page: 4494
  year: 2021
  end-page: 4521
  article-title: Interrogating in vivo T‐cell metabolism in mice using stable isotope labeling metabolomics and rapid cell sorting
  publication-title: Nature Protocols
– ident: e_1_2_9_13_1
  doi: 10.1158/2326-6066.CIR-20-0384
– ident: e_1_2_9_32_1
  doi: 10.1016/j.cmet.2021.09.004
– ident: e_1_2_9_60_1
  doi: 10.1083/jcb.201501101
– ident: e_1_2_9_82_1
  doi: 10.1016/j.eclinm.2021.101213
– ident: e_1_2_9_30_1
  doi: 10.1038/nature24302
– ident: e_1_2_9_66_1
  doi: 10.1038/s43018-022-00338-5
– ident: e_1_2_9_88_1
  doi: 10.1101/gad.191056.112
– ident: e_1_2_9_16_1
  doi: 10.1126/science.aay5516
– ident: e_1_2_9_35_1
  doi: 10.1038/s41586-019-1601-9
– ident: e_1_2_9_61_1
  doi: 10.2337/db10-0452
– ident: e_1_2_9_57_1
  doi: 10.1016/j.celrep.2017.09.065
– ident: e_1_2_9_81_1
  doi: 10.1016/j.ygyno.2021.01.029
– ident: e_1_2_9_19_1
  doi: 10.1158/2159-8290.CD-21-1077
– ident: e_1_2_9_20_1
  doi: 10.3389/fimmu.2018.02826
– ident: e_1_2_9_93_1
  doi: 10.1038/s42003-022-03422-9
– ident: e_1_2_9_58_1
  doi: 10.1038/s41467-018-04361-y
– ident: e_1_2_9_28_1
  doi: 10.1038/s41590-018-0251-7
– ident: e_1_2_9_17_1
  doi: 10.3389/fphar.2022.982424
– ident: e_1_2_9_92_1
  doi: 10.1371/journal.pone.0218126
– ident: e_1_2_9_10_1
  doi: 10.1016/j.cell.2015.08.016
– ident: e_1_2_9_21_1
  doi: 10.1038/s41568-019-0198-5
– ident: e_1_2_9_23_1
  doi: 10.1038/s41586-021-04049-2
– ident: e_1_2_9_40_1
  doi: 10.1172/JCI120803
– ident: e_1_2_9_59_1
  doi: 10.1016/j.jhepr.2021.100346
– ident: e_1_2_9_70_1
  doi: 10.1016/j.ccell.2020.09.004
– ident: e_1_2_9_2_1
– ident: e_1_2_9_5_1
  doi: 10.4049/jimmunol.2001152
– ident: e_1_2_9_3_1
  doi: 10.1038/s42255-020-00317-z
– ident: e_1_2_9_56_1
  doi: 10.1172/JCI41636
– ident: e_1_2_9_89_1
  doi: 10.1093/jncics/pkaa007
– ident: e_1_2_9_72_1
  doi: 10.1016/j.immuni.2019.09.003
– ident: e_1_2_9_90_1
  doi: 10.1001/jamaoncol.2019.5241
– ident: e_1_2_9_22_1
  doi: 10.1200/JCO.2016.67.9712
– ident: e_1_2_9_36_1
  doi: 10.1038/s41586-022-04536-0
– ident: e_1_2_9_52_1
  doi: 10.1038/nature18629
– ident: e_1_2_9_26_1
  doi: 10.1038/nature20791
– ident: e_1_2_9_6_1
  doi: 10.1007/s10875-019-00737-x
– ident: e_1_2_9_74_1
  doi: 10.1038/s41577-021-00537-8
– ident: e_1_2_9_15_1
  doi: 10.3389/fimmu.2022.915837
– ident: e_1_2_9_12_1
  doi: 10.1073/pnas.1804149115
– ident: e_1_2_9_11_1
  doi: 10.1016/j.cmet.2016.06.007
– ident: e_1_2_9_91_1
  doi: 10.1016/S1470-2045(18)30078-0
– ident: e_1_2_9_78_1
  doi: 10.1016/j.stem.2021.08.007
– ident: e_1_2_9_62_1
  doi: 10.1038/s41591-021-01232-w
– ident: e_1_2_9_38_1
  doi: 10.4049/jimmunol.1600810
– ident: e_1_2_9_76_1
  doi: 10.1038/s41586-020-2040-3
– ident: e_1_2_9_85_1
  doi: 10.1038/s42255-018-0014-7
– ident: e_1_2_9_8_1
  doi: 10.1016/j.immuni.2020.01.006
– ident: e_1_2_9_29_1
  doi: 10.1016/j.ccr.2014.07.001
– ident: e_1_2_9_64_1
  doi: 10.1038/s41587-020-0442-2
– ident: e_1_2_9_37_1
  doi: 10.1038/s41577-019-0162-3
– ident: e_1_2_9_41_1
  doi: 10.1172/JCI96061
– ident: e_1_2_9_43_1
  doi: 10.1126/science.1225152
– ident: e_1_2_9_48_1
  doi: 10.1016/j.cell.2021.05.020
– ident: e_1_2_9_4_1
  doi: 10.1038/s41591-018-0221-5
– ident: e_1_2_9_45_1
  doi: 10.1016/j.cell.2017.12.033
– ident: e_1_2_9_65_1
  doi: 10.1016/j.cell.2020.06.032
– ident: e_1_2_9_80_1
  doi: 10.1016/j.ejca.2013.03.015
– ident: e_1_2_9_18_1
  doi: 10.1002/hep.32424
– ident: e_1_2_9_14_1
  doi: 10.1016/j.cmet.2022.06.008
– ident: e_1_2_9_55_1
  doi: 10.1038/s41577-019-0124-9
– ident: e_1_2_9_25_1
  doi: 10.1016/j.cmet.2017.01.016
– ident: e_1_2_9_53_1
  doi: 10.1073/pnas.1708194114
– ident: e_1_2_9_54_1
  doi: 10.1038/s41586-021-03478-3
– ident: e_1_2_9_24_1
  doi: 10.1038/nature17173
– ident: e_1_2_9_86_1
  doi: 10.3389/fchem.2021.669308
– ident: e_1_2_9_27_1
  doi: 10.1084/jem.20210042
– ident: e_1_2_9_63_1
  doi: 10.1016/j.cell.2022.03.011
– ident: e_1_2_9_73_1
  doi: 10.1016/j.cmet.2022.07.012
– ident: e_1_2_9_87_1
  doi: 10.1038/sj.ejhg.5201630
– ident: e_1_2_9_68_1
  doi: 10.1038/s41586-022-04898-5
– ident: e_1_2_9_9_1
  doi: 10.1038/s41422-020-0379-5
– ident: e_1_2_9_79_1
  doi: 10.3389/fsurg.2022.943544
– ident: e_1_2_9_39_1
  doi: 10.1038/nm863
– ident: e_1_2_9_44_1
  doi: 10.1038/nature14052
– ident: e_1_2_9_51_1
  doi: 10.1038/nature15514
– ident: e_1_2_9_67_1
  doi: 10.1016/j.cmet.2022.09.023
– ident: e_1_2_9_33_1
  doi: 10.1038/s42255-020-0261-2
– ident: e_1_2_9_7_1
  doi: 10.1038/s41436-018-0022-8
– ident: e_1_2_9_49_1
  doi: 10.1126/science.aba8310
– ident: e_1_2_9_75_1
  doi: 10.1038/s41574-019-0230-6
– ident: e_1_2_9_34_1
  doi: 10.1038/nature14228
– ident: e_1_2_9_46_1
  doi: 10.1126/science.aat6280
– ident: e_1_2_9_94_1
  doi: 10.1016/j.immuni.2017.03.019
– ident: e_1_2_9_50_1
  doi: 10.1038/nature15541
– ident: e_1_2_9_84_1
  doi: 10.1371/journal.pone.0029539
– ident: e_1_2_9_31_1
  doi: 10.1016/j.cmet.2018.10.012
– ident: e_1_2_9_95_1
  doi: 10.1016/j.cmet.2020.03.004
– ident: e_1_2_9_47_1
  doi: 10.1126/science.aax6624
– ident: e_1_2_9_69_1
  doi: 10.1038/s41586-021-04075-0
– ident: e_1_2_9_71_1
  doi: 10.1038/s41596-021-00586-2
– ident: e_1_2_9_83_1
  doi: 10.1038/s41590-021-01044-7
– ident: e_1_2_9_42_1
  doi: 10.1016/j.cmet.2018.04.022
– ident: e_1_2_9_77_1
  doi: 10.1016/j.stem.2021.03.001
SSID ssj0012847
Score 2.4437485
Snippet Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 38
SubjectTerms Cancer
Humans
Immune System
Immunity
immunometabolism
immunotherapy
Metabolic Networks and Pathways
Metabolic pathways
Metabolism
Microbiomes
Neoplasms - metabolism
New technology
Obesity
Obesity - metabolism
Obesity - therapy
Pathogenesis
Therapeutic targets
Tumor cells
Tumor Microenvironment
Tumors
Title Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnyas.14976
https://www.ncbi.nlm.nih.gov/pubmed/36960914
https://www.proquest.com/docview/2812369804
https://www.proquest.com/docview/2791367774
https://pubmed.ncbi.nlm.nih.gov/PMC10367315
Volume 1523
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwEB1VRUhcgJaPLi2VERwoUqqs48SJxGULrAqIHigrlQOKbMcRFd2karKH5cSP4BfyS5ixk9ClCAlukTyR4_jN-DkZvwF4UliErrBFUJgINyhlnAU6szoYR9omqVFGOgHTd0fJ4Uy8OYlP1uB5fxbG60MMH9zIM1y8JgdXurnk5NVSNejnuJxiAKZkLWJE7wftKBd3XRiWGIaRxnTapJTG8-vW1dXoCsW8mil5mcG6JWh6Cz71D-8zT77sL1q9b77-puv4v6O7DTc7bsomHkwbsGarTbjuq1UuN2GjiwMNe9qJVe_dgdlrOmBSz22LaDo7beZMtQxJJfMDrlXRsLpkta8_wFRVMENAu_jx7btibxFHpAbOjpdzSh9TzP_DuAuz6asPLw6DrlRDYITIkoDiRFIUJlNSYxAJS5z5NI1EhHSkEFbKmJc6KS1t9yzPxplIVExipzYs01DH0T1Yr7C7LWAcGRKXZcR1XArJS2VTOj5sQsUTFWkxgr1-ynLT6ZhTOY2zvN_P0LvL3bsbwePB9tyrd_zRaqef-bzz4CbnKenSZGmIHT4amtH36IeKqmy9QBuZkeIdMugR3PdAGbqhOok4eGxJVyA0GJCu92pLdfrZ6XuPkVXIaByP4JmDyF8ePT_6ODl2Vw_-xXgbbnAkaz5xcwfW24uFfYjkqtW7cG1y8PJguuuc6Sd_aSPU
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwEB5VRQguQMvf0gJGgESRUmWd_0MPFaXape0eaFcqp9R2HFHRTVCTVbWceAheg1fhIfokzNhJ6FKExKEHbpE8kv9mxt_E428AXmQaVdfXmZMpDwOUPEgcmWjp9D2pw1gJFRkC071ROBj77w6DwwX43r6FsfwQ3Q83sgzjr8nA6Yf0BSsvZqJCQ8fztMmp3NGzM4zYqo3hFm7vS8633x68GThNUQFH-X4SOqTRYZapREQS1d3NcYxx7PkeHpyZr6Mo4LkMc02BieYJxvihCIiWU7t57EoqEoEe_xqVECeq_q33HVuV8fTG8Ufo-BE4NWyolDj0a6zz598lUHs5N_MiZjaH3vZt-NEul811-bQ-reW6-vIbk-R_s5534FYDv9mmtZclWNDFMly3BTlny7DUuLqKvWr4uNfuwnhIb2jKia7RYE6OqwkTNUPczOwKlyKrWJmz0pZYYKLImCJbOj3_-k0wnB7ha832ZxPKkBPMXtPcg_GVTPQ-LBbY3UNgHEEgj3KPyyD3I54LHdMLaeUKHgpP-j1Ya3UkVQ1VO1UMOUnbkI32KjV71YPnnexnS1DyR6nVVtXSxklVKY-JeieJXezwWdeM7oXujEShyynKRAmR-mGQ0IMHVjO7bqgUJE4eW-I5ne0EiLp8vqU4_mgozPsInCKvH_TgtdHJvww9HX3Y3Ddfj_5F-CncGBzs7aa7w9HOCtzkiE1tnuoqLNanU_0YsWQtnxgLZnB01Sr-Ex1yfEg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtQwEB5VRSAuQAuUhQJGgESRUmWd_wOHimXVpbBClJXKKbUTW1R0k6rJqtqeeAgeg1fhJXgSZuwkdClC4tADt0geyX8z42_i8TcAT3KFquur3MkzDwMUHSSOTJR0-p5UYZyJLDIEpm_H4fbEf70X7C3Bt_YtjOWH6H64kWUYf00GfpTrM0ZezEWFdo7HaZNSuaPmJxiwVS9GA9zdp5wPX314ue00NQWczPeT0CGFDvM8S0QkUdtdjUOMY8_38NzMfRVFAdcy1IriEsUTDPFDERArp3J17EqqEYEO_5IfugkVihi878iqjKM3fj9Cv4-4qSFDpbyhX2NdPP7OYdrzqZlnIbM584bX4Xu7WjbV5fPmrJab2elvRJL_y3LegGsN-GZb1lpWYEkVq3DZluOcr8JK4-gq9qxh4964CZMRvaApp6pGczk8qKZM1AxRM7MLXIq8YqVmpS2wwESRs4ws6fjHl6-C4fQIXSu2O59Sfpxg9pLmFkwuZKK3YbnA7u4A4wgBeaQ9LgPtR1wLFdP76MwVPBSe9Huw0apImjVE7VQv5DBtAzbaq9TsVQ8ed7JHlp7kj1LrraaljYuqUh4T8U4Su9jho64ZnQvdGIlClTOUiRKi9MMQoQdrVjG7bqgQJE4eW-IFle0EiLh8saU4-GQIzPsImyKvH_TguVHJvww9HX_c2jVfd_9F-CFceTcYpm9G4517cJUjMLVJquuwXB_P1H0EkrV8YOyXwf5Fa_hPFoB69w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immunometabolism+at+the+crossroads+of+obesity+and+cancer%E2%80%94a+Keystone+Symposia+report&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.au=Cable%2C+Jennifer&rft.au=Rathmell%2C+Jeffrey+C.&rft.au=Pearce%2C+Erika+L.&rft.au=Ho%2C+Ping-Chih&rft.date=2023-05-01&rft.issn=0077-8923&rft.eissn=1749-6632&rft.volume=1523&rft.issue=1&rft.spage=38&rft.epage=50&rft_id=info:doi/10.1111%2Fnyas.14976&rft_id=info%3Apmid%2F36960914&rft.externalDocID=PMC10367315
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0077-8923&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0077-8923&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0077-8923&client=summon