LEF1 isoforms regulate cellular senescence and aging

• Published in: Aging cell Vol. 22; no. 12; pp. e14024 - n/a
• Main Authors: Jia, Minxue, Sayed, Khaled, Kapetanaki, Maria G., Dion, William, Rosas, Lorena, Irfan, Saad, Valenzi, Eleanor, Mora, Ana L., Lafyatis, Robert A., Rojas, Mauricio, Zhu, Bokai, Benos, Panayiotis V.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2023; John Wiley and Sons Inc
• Subjects: Age; Aged; Aging; Aging - genetics; Animals; Automation; Cell culture; Cells; cellular senescence; Cellular Senescence - genetics; Comparative analysis; Datasets; Fibrosis; Gene expression; Gene regulation; Histopathology; Humans; IPF; Isoforms; LEF1; lung; Lung - pathology; Lung diseases; Lungs; Lymphocytes T; Lymphoid Enhancer-Binding Factor 1 - genetics; Lymphoid Enhancer-Binding Factor 1 - metabolism; Macrophages; Mice; Protein Isoforms - genetics; Senescence; lung; cellular senescence; aging; IPF; LEF1

The study of aging and its mechanisms, such as cellular senescence, has provided valuable insights into age‐related pathologies, thus contributing to their prevention and treatment. The current abundance of high‐throughput data combined with the surge of robust analysis algorithms has facilitated no...