Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress‐apoptosis gene expression in PBMCs of women with PCOS

• Published in: Journal of cellular and molecular medicine Vol. 28; no. 14; pp. e18464 - n/a
• Main Authors: Jabarpour, Masoome, Amidi, Fardin, Aleyasin, Ashraf, Nashtaei, Maryam Shabani, Marghmaleki, Mojtaba Saedi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2024; John Wiley and Sons Inc
• Subjects: Adolescent; Adult; Anti-inflammatory agents; Apoptosis; Apoptosis - drug effects; Astaxanthin; Biomarkers - blood; Cardiovascular disease; Caspase 8 - genetics; Caspase 8 - metabolism; Caspase-3; Caspase-8; Clinical trials; Cytokines; Diabetes; Dietary Supplements; Double-Blind Method; Endoplasmic reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress - drug effects; Enzyme-linked immunosorbent assay; ER stress; Exercise; Female; Gene expression; Gene Expression Regulation - drug effects; Glucose; Hair loss; Hirsutism; Humans; Infertility; Inflammation; Inflammation - blood; Inflammation - drug therapy; Inflammation - genetics; inflammatory markers; Interleukin-18 - blood; Interleukin-18 - genetics; Interleukin-6 - blood; Interleukin-6 - genetics; Kinases; Leukocytes (mononuclear); Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Menstrual cycle; Menstruation; Metabolism; Original; Patients; PBMC; Peripheral blood mononuclear cells; Placebos; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - genetics; Proteins; Statistical analysis; Transcription factors; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Womens health; Xanthophylls - administration & dosage; Xanthophylls - pharmacology; Xanthophylls - therapeutic use; Young Adult; Iran; Germany; ER stress; inflammatory markers; apoptosis; PBMC; astaxanthin; polycystic ovary syndrome

Polycystic ovarian syndrome (PCOS) is related to pro‐apoptotic and pro‐inflammatory conditions generated by Endoplasmic reticulum (ER) stress. This study aimed to determine the effect of Astaxanthin (ASX), as carotenoid with potent antioxidant and anti‐inflammatory properties, on serum inflammatory...