Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress‐apoptosis gene expression in PBMCs of women with PCOS - Jabarpour, Masoome; Amidi, Fardin; Aleyasin, Ashraf; Nashtaei, Maryam Shabani; Marghmaleki, Mojtaba Saedi (Journal of cellular and molecular medicine, 2024)
Keywords: Adolescent; Adult; Anti-inflammatory agents; Apoptosis; Apoptosis - drug effects; Astaxanthin; Biomarkers - blood; Cardiovascular disease; Caspase 8 - genetics; Caspase 8 - metabolism; Caspase-3; Caspase-8; Clinical trials; Cytokines; Diabetes; Dietary Supplements; Double-Blind Method; Endoplasmic reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress - drug effects; Enzyme-linked immunosorbent assay; ER stress; Exercise; Female; Gene expression; Gene Expression Regulation - drug effects; Glucose; Hair loss; Hirsutism; Humans; Infertility; Inflammation; Inflammation - blood; Inflammation - drug therapy; Inflammation - genetics; inflammatory markers; Interleukin-18 - blood; Interleukin-18 - genetics; Interleukin-6 - blood; Interleukin-6 - genetics; Kinases; Leukocytes (mononuclear); Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Menstrual cycle; Menstruation; Metabolism; Original; Patients; PBMC; Peripheral blood mononuclear cells; Placebos; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - drug therapy; Polycystic Ovary Syndrome - genetics; Proteins; Statistical analysis; Transcription factors; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Womens health; Xanthophylls - administration & dosage; Xanthophylls - pharmacology; Xanthophylls - therapeutic use; Young Adult; Iran; Germany; ER stress; inflammatory markers; apoptosis; PBMC; astaxanthin; polycystic ovary syndrome