Analysis of neutrophil extracellular trap‐related genes in Crohn's disease based on bioinformatics

• Published in: Journal of cellular and molecular medicine Vol. 28; no. 16; pp. e70013 - n/a
• Main Authors: Chen, Libin, Ai, Feiyan, Wu, Xing, Yu, Wentao, Jin, Xintong, Ma, Jian, Xiang, Bo, Shen, Shourong, Li, Xiayu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2024; John Wiley and Sons Inc
• Subjects: Bioinformatics; biomarker; Biomarkers; Biopsy; CD4 antigen; Chemokines; Colon; Computational Biology - methods; Crohn Disease - genetics; Crohn Disease - immunology; Crohn Disease - pathology; Crohn's disease; Cytokines; Databases, Genetic; Datasets; Extracellular Traps - genetics; Extracellular Traps - metabolism; Gastrointestinal tract; Gene expression; Gene Expression Omnibus; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genomes; Humans; immune infiltration; Inflammatory bowel diseases; Interferon regulatory factor 1; Leukocytes (neutrophilic); Macrophages; Microbicides; neutrophil extracellular traps; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Original; Pathogens; Phenotypes; Protein Interaction Maps - genetics; Proteins; Rheumatoid arthritis; Software; Statistical models; Systemic lupus erythematosus; Therapeutic applications; Tissue inhibitor of metalloproteinase 1; Crohn's disease; neutrophil extracellular traps; immune infiltration; biomarker; Gene Expression Omnibus; bioinformatics

Crohn's disease (CD) presents with diverse clinical phenotypes due to persistent inflammation of the gastrointestinal tract. Its global incidence is on the rise. Neutrophil extracellular traps (NETs) are networks released by neutrophils that capture microbicidal proteins and oxidases targeting...