Longitudinal Multiparametric Quantitative MRI Evaluation of Acute and Chronic Multiple Sclerosis Paramagnetic Rim Lesions

• Published in: Journal of magnetic resonance imaging Vol. 61; no. 4; pp. 1812 - 1828
• Main Authors: Elkady, Ahmed M., Elliott, Colm, Fetco, Dumitru, Araujo, David, Karimaghaloo, Zahra, Ganzetti, Marco, Clayton, David, Craveiro, Licinio, Kazlauskaite, Agne, Narayanan, Sridar, Arnold, Douglas L., Rudko, David A.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2025; Wiley Subscription Services, Inc
• Subjects: Acute Disease; Adult; Bioaccumulation; Brain - diagnostic imaging; Chronic Disease; Damage accumulation; Female; Field strength; Humans; Image Processing, Computer-Assisted; Iron; Lesions; Longitudinal Studies; Magnetic permeability; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic susceptibility; Male; Middle Aged; Multiparametric Magnetic Resonance Imaging - methods; Multiple sclerosis; Multiple Sclerosis - diagnostic imaging; Myelin; paramagnetic rim lesions; quantitative susceptibility mapping; R2 mapping; Recovery; Retrospective Studies; Statistical analysis; Statistical models; Statistical tests; T1w/T2w; myelin; T1w/T2w; iron; quantitative susceptibility mapping; R2 mapping; paramagnetic rim lesions

Background Multiple sclerosis (MS) paramagnetic rim lesions (PRLs) are markers of chronic active biology and exhibit complex iron and myelin changes that may complicate quantification when using conventional MRI approaches. Purpose To conduct a multiparametric MRI analysis of PRLs. Study Type Retros...