Irisin preserves mitochondrial integrity and function in tubular epithelial cells after ischemia–reperfusion‐induced acute kidney injury

• Published in: Acta Physiologica Vol. 240; no. 9; pp. e14211 - n/a
• Main Authors: Cui, Yu, Yu, Lu, Cong, Wenqi, Jiang, Shan, Qiu, Xingyu, Wei, Chunchun, Zheng, Gui, Mao, Jianhua, Liu, Ruisheng, Patzak, Andreas, Persson, Pontus B., Chen, Jianghua, Zhao, Liang, Lai, En Yin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2024
• Subjects: acute kidney injury; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Autophagy; Confocal microscopy; Creatinine; Epithelial cells; Epithelial Cells - metabolism; Female; Fibronectins - metabolism; Gelatinase; Humans; Immunohistochemistry; inflammasome activation; irisin; Ischemia; Kidney Tubules - metabolism; Kidney Tubules - pathology; Kidneys; Kinases; Leukocytes (neutrophilic); Lipocalin; Male; Membrane proteins; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria - metabolism; mitochondrial autophagy; Movement disorders; Neurodegenerative diseases; Parkinson's disease; Proteins; Proximal tubules; PTEN protein; PTEN-induced putative kinase; Renal function; renal ischemia–reperfusion; Reperfusion; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Skeletal muscle; Translocase; inflammasome activation; mitochondrial autophagy; acute kidney injury; irisin; renal ischemia–reperfusion

Aims A myokine secreted by skeletal muscles during exercise called irisin mitigates ischemia–reperfusion (I/R) injury in epithelial cells of various organs by limiting damage to mitochondria. We test whether irisin may preserve the mitochondrial integrity and function in renal tubular epithelial cel...