Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age‐dependent fashion and induces cell senescence via GDF15 - Chiariello, Antonio; Rossetti, Luca; Valente, Sabrina; Pasquinelli, Gianandrea; Sollazzo, Manuela; Iommarini, Luisa; Porcelli, Anna Maria; Tognocchi, Monica; Conte, Giuseppe; Santoro, Aurelia; Kwiatkowska, Katarzyna M.; Garagnani, Paolo; et al. (Aging cell, 2024)
Keywords: Adult; Aged; Aging - genetics; Aging - metabolism; Alzheimer's disease; cell senescence; Cells, Cultured; Cellular Senescence - genetics; Down-Regulation; Enzymes; Fibroblasts; Fibroblasts - metabolism; GDF15; Gene expression; Growth Differentiation Factor 15 - genetics; Growth Differentiation Factor 15 - metabolism; Homeostasis; human aging; Humans; lipid metabolism; Lipids; Male; Metabolic disorders; Metabolism; Mitochondria; Mitochondria - metabolism; mitochondrial dysfunction; Perilipin-2 - genetics; Perilipin-2 - metabolism; PLIN2; Proteins; Respiration; Senescence; Statistical analysis; PLIN2; mitochondrial dysfunction; GDF15; human aging; lipid metabolism; cell senescence