Reduced‐volume radiotherapy versus conventional‐volume radiotherapy after induction chemotherapy in nasopharyngeal carcinoma: An open‐label, noninferiority, multicenter, randomized phase 3 trial

• Published in: CA: a cancer journal for clinicians Vol. 75; no. 3; pp. 203 - 215
• Main Authors: Tang, Ling‐Long, Chen, Lin, Xu, Gui‐Qiong, Zhang, Ning, Huang, Cheng‐Long, Li, Wen‐Fei, Mao, Yan‐Ping, Zhou, Guan‐Qun, Lei, Feng, Chen, Lu‐Si, Huang, Shao Hui, Chen, Lei, Chen, Yu‐Pei, Zhang, Yuan, Liu, Xu, Xu, Cheng, Zhao, Yin, Li, Ji‐Bin, Liu, Na, Xie, Fang‐Yun, Guo, Rui, Sun, Ying, Ma, Jun
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2025; John Wiley and Sons Inc
• Subjects: Adult; Aged; Chemotherapy; clinical trial; Female; Humans; Induction Chemotherapy; Male; Middle Aged; Mucositis; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - drug therapy; Nasopharyngeal Carcinoma - mortality; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - radiotherapy; noninferiority; Otitis media; Public health; Quality of Life; Radiation Injuries - epidemiology; Radiation therapy; reduced‐volume radiotherapy; Saliva; Survival; Toxicity; Tumor Burden - drug effects; Tumor Burden - radiation effects; Tumors; clinical trial; nasopharyngeal carcinoma; reduced‐volume radiotherapy; noninferiority

Background Nearly 90% locoregionally advanced nasopharyngeal carcinoma (LANPC) responds to induction chemotherapy (IC) with significant tumor volume shrinkage. Radiotherapy always follows IC, and reduced volume has been proposed. However, the efficacy and safety of reduced‐volume radiotherapy is unc...