Collagen XV Is Necessary for Modeling of the Extracellular Matrix and Its Deficiency Predisposes to Cardiomyopathy

• Published in: Circulation research Vol. 107; no. 10; pp. 1241 - 1252
• Main Authors: Rasi, Karolina, Piuhola, Jarkko, Czabanka, Marcus, Sormunen, Raija, Ilves, Mika, Leskinen, Hanna, Rysä, Jaana, Kerkelä, Risto, Janmey, Paul, Heljasvaara, Ritva, Peuhkurinen, Keijo, Vuolteenaho, Olli, Ruskoaho, Heikki, Vajkoczy, Peter, Pihlajaniemi, Taina, Eklund, Lauri
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 12.11.2010; Lippincott Williams & Wilkins
• Subjects: Age Factors; Aging; Angiotensin II; Animals; Arterial hypertension. Arterial hypotension; Atrial Natriuretic Factor - genetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiomyopathies - etiology; Cardiomyopathies - genetics; Cardiomyopathies - metabolism; Cardiomyopathies - physiopathology; Collagen - deficiency; Collagen - genetics; Collagen - metabolism; Coronary Circulation; Disease Models, Animal; Echocardiography; Elasticity; Enzyme Inhibitors; Extracellular Matrix - metabolism; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling - methods; Gene Expression Regulation; Genotype; Heart; Heart Ventricles - metabolism; Heart Ventricles - physiopathology; Hemodynamics; Hypertension - chemically induced; Hypertension - complications; Hypertension - genetics; Hypertension - metabolism; Hypertension - physiopathology; Male; Medical sciences; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Microscopy, Electron; Microscopy, Video; Myocarditis. Cardiomyopathies; Myocardium - metabolism; Myocardium - ultrastructure; Natriuretic Peptide, Brain - genetics; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase - metabolism; Phenotype; Polymerase Chain Reaction; RNA, Messenger - metabolism; Telemetry; Ventricular Remodeling; Vertebrates: cardiovascular system; Hypertension; Cardiomyopathy; Glycoprotein; Cardiovascular disease; Myocardial disease; Modeling; Microcirculation; Vertebrata; Mammalia; Heart disease; Collagen; Extracellular matrix; Circulatory system

RATIONALE:The extracellular matrix (ECM) is a major determinant of the structural integrity and functional properties of the myocardium in common pathological conditions, and changes in vasculature contribute to cardiac dysfunction. Collagen (Col) XV is preferentially expressed in the ECM of cardiac...