Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 30; no. 1; pp. 229 - 19
• Main Authors: Gong, Yingying, Wei, Meilin, Cao, Xiaopei, Xu, Changliu, Jin, Jiewen, Pei, Ling, Li, Yanbing, Xiao, Haipeng, Wu, Liting
• Format: Journal Article
• Language: English
• Published: England BioMed Central 23.11.2024; BMC
• Subjects: Alternative Splicing; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; ChREBP; circMlxipl; Cloning; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diet, High-Fat - adverse effects; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation; Glucose; Hdac3; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Insulin; Insulin-Secreting Cells - metabolism; Lipotoxic β-cells; Male; Mbnl1; Mice; Palmitic Acid; Rbbp6; RNA, Circular - genetics; RNA, Circular - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; United Kingdom > UK; United States > US; China; Hdac3; Rbbp6; ChREBP; Lipotoxic β-cells; Mbnl1; circMlxipl

Diabetes, a global epidemic, is the leading cause of mortality globally. The aim of this study is to get better understanding of pathophysiology of diabetes. Palmitic acid (PA)-treated β-cells, db/db mice and high fat diet (HFD)-fed mouse model of type 2 diabetes were established. H&E was used t...