Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage - Gong, Yingying; Wei, Meilin; Cao, Xiaopei; Xu, Changliu; Jin, Jiewen; Pei, Ling; Li, Yanbing; Xiao, Haipeng; Wu, Liting (Molecular medicine (Cambridge, Mass.), 2024)
Keywords: Alternative Splicing; Animals; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; ChREBP; circMlxipl; Cloning; Diabetes; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diet, High-Fat - adverse effects; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation; Glucose; Hdac3; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Insulin; Insulin-Secreting Cells - metabolism; Lipotoxic β-cells; Male; Mbnl1; Mice; Palmitic Acid; Rbbp6; RNA, Circular - genetics; RNA, Circular - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; United Kingdom--UK; United States--US; China; Hdac3; Rbbp6; ChREBP; Lipotoxic β-cells; Mbnl1; circMlxipl