Small dense LDL cholesterol in human subjects with different chronic inflammatory diseases

• Published in: Nutrition, metabolism, and cardiovascular diseases Vol. 28; no. 11; pp. 1100 - 1105
• Main Authors: Schulte, D.M., Paulsen, K., Türk, K., Brandt, B., Freitag-Wolf, S., Hagen, I., Zeuner, R., Schröder, J.O., Lieb, W., Franke, A., Nikolaus, S., Mrowietz, U., Gerdes, S., Schreiber, S., Laudes, M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2018
• Subjects: Adult; Aged; Anti-Inflammatory Agents - therapeutic use; antibodies; Atherosclerosis - blood; Atherosclerosis - diagnosis; Atherosclerosis - immunology; Biomarkers - blood; cardiovascular diseases; Case-Control Studies; Cholesterol, LDL - blood; Chronic Disease; Chronic inflammatory disease; clinical trials; drug therapy; Dyslipidemia; Female; females; Germany; Humans; Inflammation; inflammatory bowel disease; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - immunology; lipid metabolism; longevity; low density lipoprotein cholesterol; Male; males; Middle Aged; observational studies; Particle Size; patients; Phenotype; Prospective Studies; psoriasis; Psoriasis - blood; Psoriasis - diagnosis; Psoriasis - drug therapy; Psoriasis - immunology; Receptors, Interleukin-6 - antagonists & inhibitors; Receptors, Interleukin-6 - immunology; Risk Factors; sdLDL; Spondylitis, Ankylosing - blood; Spondylitis, Ankylosing - diagnosis; Spondylitis, Ankylosing - drug therapy; Spondylitis, Ankylosing - immunology; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - immunology; Germany; sdLDL; Inflammation; Chronic inflammatory disease; Dyslipidemia

Chronic inflammatory diseases (CID) are associated with a profound increase in cardiovascular (CV) risk resulting in reduced life expectancy. However, LDL-cholesterol is reported to be low in CID patients which is referred to as the “LDL paradoxon”. The aim of the present study was to investigate wh...