Competitive inhibition of iron absorption by manganese and zinc in humans

• Published in: The American journal of clinical nutrition Vol. 54; no. 1; pp. 152 - 156
• Main Authors: Rossander-Hultén, L, Brune, M, Sandström, B, Lönnerdal, B, Hallberg, L
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1991; American Society for Clinical Nutrition
• Subjects: ABSORCION; ABSORPTION; Absorption - drug effects; Adult; ADULTE; ADULTOS; adults; Binding, Competitive; Biological and medical sciences; CINC; dose response; drug effects; Female; FEMME; FER; Food; Fundamental and applied biological sciences. Psychology; HIERRO; HOMBRES; HOMME; human; Humans; INHIBICION; INHIBITION; Intestine. Mesentery; Iron; Iron - pharmacokinetics; Iron absorption; Male; MANGANESE; Manganese - pharmacology; MANGANESO; men; Middle Aged; MUJERES; nutrient-nutrient interactions; pharmacokinetics; pharmacology; SUECIA; SUEDE; Sweden; trace element interactions; Vertebrates: digestive system; women; ZINC; Zinc - pharmacology; Sweden; trace element interactions; Iron absorption; human; manganese; zinc; Competition; Human; Absorption; Oligoelement; Radiolabelling; Digestive system; Iron; Zinc; Manganese

Zinc and manganese may interfere with iron absorption because of similar physicochemical properties and shared absorptive pathways. The effects of zinc and manganese on iron absorption were studied in human subjects by using paired observations and a dual-radioisotope method (55Fe and59Fe). Manganes...