Large Fecal Reservoir of Escherichia coli Sequence Type 131-H30 Subclone Strains That Are Shared Within Households and Resemble Clinical ST131-H30 Isolates

• Published in: The Journal of infectious diseases Vol. 221; no. 10; pp. 1659 - 1668
• Main Authors: Mohamed, Muhanad, Clabots, Connie, Porter, Stephen B, Bender, Tricia, Thuras, Paul, Johnson, James R
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 27.04.2020
• Subjects: Adult; Animals; Anti-Bacterial Agents - pharmacology; Antibiotics; Child; Clinical isolates; Colonization; Disease transmission; Drug Resistance, Bacterial; E coli; Escherichia coli; Escherichia coli - classification; Escherichia coli - genetics; Escherichia coli - pathogenicity; Family Characteristics; Feces; Feces - microbiology; Female; Genotype; Households; Humans; Intestine; Major and Brief Reports; Male; Pandemics; Pets; Phylogeny; Strains (organisms); Virulence; strain sharing; intestinal colonization; fluoroquinolone resistance; ST131; Escherichia coli

Abstract Background Emerging antimicrobial-resistant Escherichia coli represent mainly the nested (fluoroquinolone-resistant [FQR]) H30R and H30Rx subclones within sequence type 131 (ST131). Intestinal colonization and within-household transmission may underlie H30R’s emergence. Methods We screened...