Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments

• Published in: Neuron (Cambridge, Mass.) Vol. 20; no. 6; pp. 1111 - 1122
• Main Authors: Hsu, S C, Hazuka, C D, Roth, R, Foletti, D L, Heuser, J, Scheller, R H
• Format: Journal Article
• Language: English
• Published: United States 01.06.1998
• Subjects: Amino Acid Sequence; Animals; Antibodies; Brain Chemistry - physiology; Carrier Proteins - analysis; Carrier Proteins - metabolism; Carrier Proteins - ultrastructure; Cell Cycle Proteins - analysis; Cell Cycle Proteins - immunology; Cells, Cultured; Cytoskeletal Proteins; Freeze Etching; GTP Phosphohydrolases; Hippocampus - cytology; Mice; Mice, Inbred BALB C; Microfilament Proteins - analysis; Microfilament Proteins - metabolism; Microfilament Proteins - ultrastructure; Molecular Sequence Data; Rabbits; Rats; Schizosaccharomyces pombe Proteins; sec protein; Septins; Spleen - cytology; Synaptic Vesicles - chemistry; Synaptic Vesicles - metabolism; Synaptic Vesicles - ultrastructure; Transcription Factors; Vesicular Transport Proteins

Both the sec6/8 complex and septin filaments have been implicated in directing vesicles and proteins to sites of active membrane addition in yeast. The rat brain sec6/8 complex coimmunoprecipitates with a filament composed of four mammalian septins, suggesting an interaction between these complexes....