Addition of Vitamin A Intake Data during Compartmental Modeling of Retinol Kinetics in Theoretical Humans Leads to Accurate Prediction of Vitamin A Total Body Stores and Kinetic Parameters in Studies of Reasonable Duration

• Published in: The Journal of nutrition Vol. 149; no. 11; pp. 2065 - 2072
• Main Authors: Ford, Jennifer Lynn, Green, Joanne Balmer, Green, Michael H
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019; Oxford University Press
• Subjects: Adult; Child, Preschool; Computer Simulation; dietary vitamin A intake; Editor's Choice; Female; Humans; Infant; Male; Methodology and Mathematical Modeling; Middle Aged; model-based compartmental analysis; Models, Biological; Reference Values; theoretical humans; Time Factors; tracer kinetics; Vitamin A - administration & dosage; Vitamin A - blood; Vitamin A - pharmacokinetics; vitamin A assessment; vitamin A total body stores; WinSAAM; Young Adult; TBS; tracer kinetics; model-based compartmental analysis; WinSAAM; RID; DR; vitamin A assessment; FDp; FSD; theoretical humans; dietary vitamin A intake; DT(I); vitamin A total body stores

Mathematical modeling of theoretical data has been used to validate experimental protocols and methods in several fields. We hypothesized that adding dietary vitamin A intake data as an input during compartmental modeling of retinol kinetics would lead to accurate prediction of vitamin A total body...