Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation via Regulating the Binding Ability of H3K9me3 with the Promoters of Runx2, Osterix and Osteocalcin

• Published in: Journal of biomedical nanotechnology Vol. 16; no. 6; p. 899
• Main Authors: Qin, Guozhong, Li, Yikai, Wang, Haibin, Yang, Junxing, Chen, Qunqun, Tang, Hongyu, Wang, Yueqi, Zhang, Meng, Jiang, Tao, Lin, Songqing, Huo, Shaochuan
• Format: Journal Article
• Language: English
• Published: United States 01.06.2020
• Subjects: Animals; Cell Differentiation; Core Binding Factor Alpha 1 Subunit - genetics; Histone Demethylases - physiology; Lysine; Osteoblasts - metabolism; Osteocalcin - genetics; Osteogenesis - genetics; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Transcription Factors - genetics; Transcription Factors - metabolism

A well-studied subject of epigenetics, the histone methylation located at lysine and arginine is overseen via methyltransferases and demethylases. Lysine-specific demethylase 4A (KDM4A) comprises a lysine demethylase and possesses specificity for H3K9me3 and H3K36me3, which is capable of being used...