Arginine-rich Anti-vascular Endothelial Growth Factor Peptides Inhibit Tumor Growth and Metastasis by Blocking Angiogenesis
Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis. Therefore, it is a prime therapeutic target fo...
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Published in | The Journal of biological chemistry Vol. 275; no. 18; pp. 13588 - 13596 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
05.05.2000
American Society for Biochemistry and Molecular Biology |
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Abstract | Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis. Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer. We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF165 with VEGF receptor (IC50 = 2–4 μm). They have no effect on binding of basic fibroblast growth factor to cellular receptor. The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF165 without toxicity. The peptides bind to VEGF and inhibit binding of both VEGF165and VEGF121, suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF121. The identified peptides block the angiogenesis induced by VEGF165in vivo in the chick chorioallantoic membrane and the rabbit cornea. Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice. Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs. |
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AbstractList | Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis. Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer. We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF sub(165) with VEGF receptor (IC sub(50) = 2-4 mu . They have no effect on binding of basic fibroblast growth factor to cellular receptor. The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF sub(165) without toxicity. The peptides bind to VEGF and inhibit binding of both VEGF sub(165) and VEGF sub(121), suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF sub(121). The identified peptides block the angiogenesis induced by VEGF sub(165) in vivo in the chick chorioallantoic membrane and the rabbit cornea. Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice. Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs. Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis. Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer. We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF 165 with VEGF receptor (IC 50 = 2â4 μ m ). They have no effect on binding of basic fibroblast growth factor to cellular receptor. The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF 165 without toxicity. The peptides bind to VEGF and inhibit binding of both VEGF 165 and VEGF 121 , suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF 121 . The identified peptides block the angiogenesis induced by VEGF 165 in vivo in the chick chorioallantoic membrane and the rabbit cornea. Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice. Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs. Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis. Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer. We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF(165) with VEGF receptor (IC(50) = 2-4 micrometer). They have no effect on binding of basic fibroblast growth factor to cellular receptor. The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF(165) without toxicity. The peptides bind to VEGF and inhibit binding of both VEGF(165) and VEGF(121), suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF(121). The identified peptides block the angiogenesis induced by VEGF(165) in vivo in the chick chorioallantoic membrane and the rabbit cornea. Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice. Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs. Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis. Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer. We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF165 with VEGF receptor (IC50 = 2–4 μm). They have no effect on binding of basic fibroblast growth factor to cellular receptor. The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF165 without toxicity. The peptides bind to VEGF and inhibit binding of both VEGF165and VEGF121, suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF121. The identified peptides block the angiogenesis induced by VEGF165in vivo in the chick chorioallantoic membrane and the rabbit cornea. Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice. Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs. |
Author | Bae, Dong-Goo Gho, Yong-Song Yoon, Wan-Hee Chae, Chi-Bom |
Author_xml | – sequence: 1 givenname: Dong-Goo surname: Bae fullname: Bae, Dong-Goo organization: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, 790-784 – sequence: 2 givenname: Yong-Song surname: Gho fullname: Gho, Yong-Song organization: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, 790-784 – sequence: 3 givenname: Wan-Hee surname: Yoon fullname: Yoon, Wan-Hee organization: Department of Surgery, College of Medicine, Chungnam National University, Tae-jun, 301-130, Korea – sequence: 4 givenname: Chi-Bom surname: Chae fullname: Chae, Chi-Bom email: cbchae@postech.ac.kr organization: Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, 790-784 |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10788475$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1210/endo.138.2.4953 10.1016/S0092-8674(00)80108-7 10.1002/(SICI)1097-0134(199611)26:3<353::AID-PROT9>3.0.CO;2-E 10.1038/297307a0 10.1016/0092-8674(91)90642-C 10.1002/j.1460-2075.1989.tb08557.x 10.1038/339058a0 10.1016/S0021-9258(18)99049-6 10.1016/0165-6147(89)90266-6 10.1038/376066a0 10.1038/380439a0 10.1038/362841a0 10.1111/j.1432-1033.1993.tb19865.x 10.1172/JCI115063 10.1038/380435a0 10.1016/0092-8674(93)90573-9 10.1073/pnas.87.7.2628 10.1074/jbc.270.19.11322 10.1073/pnas.92.5.1307 10.1126/science.2432664 10.1073/pnas.95.15.8795 10.1074/jbc.270.25.15059 10.1016/S0021-9258(19)47212-8 10.1093/jnci/87.3.213 10.1126/science.2479986 10.1073/pnas.88.20.9267 10.1038/376062a0 10.1016/S0968-0004(97)01074-8 10.1126/science.1312256 10.1038/367576a0 10.1073/pnas.86.19.7311 10.1038/386671a0 10.1006/bbrc.1996.0730 10.1002/glia.440150313 10.1002/jcp.1041490108 10.1007/BF00666036 10.1016/0958-1669(95)80111-1 10.1073/pnas.76.11.5674 10.1073/pnas.88.13.5819 10.1006/bbrc.1993.1955 10.1172/JCI107470 10.1006/bbrc.1996.0806 10.1038/nm1197-1222 10.1126/science.2479987 10.1016/0024-3205(93)90113-H |
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References | Conn, Bayne, Soderman, Kwok, Sullivan, Palisi, Hope, Thomas (bib11) 1990; 87 Gospodarowicz, Abraham, Schilling (bib8) 1989; 86 Dvorak, Brown, Detmar, Dvorak (bib51) 1995; 146 Taylor, Folkman (bib44) 1982; 297 Park, Kim, Lee, Seo, Suh, Cho, Ryu, Chae (bib27) 1997; 138 Hanahan, Folkman (bib5) 1996; 86 Siemeister, Schnurr, Mohrs, Schachtele, Marme, Martiny-Baron (bib30) 1996; 222 Folkman, Watson, Ingber, Hanahan (bib45) 1989; 339 Pinilla, Appel, Blanc, Houghten (bib28) 1992; 13 Bikfalvi, Sauzeau, Moukadiri, Maclouf, Busso, Bryckaert, Plouet, Tobelem (bib38) 1991; 149 Kim, Li, Winer, Armanini, Gillett, Phillips, Ferrara (bib22) 1993; 362 Bussolino, Mantovani, Persico (bib7) 1997; 22 Zhang, Craft, Scott, Ziche, Weich, Harris, Bicknell (bib21) 1995; 87 De Blasi, O'Reilly, Motulsky (bib39) 1989; 10 Martiny-Baron, Marme (bib25) 1995; 6 Liotta, Steeg, Stetler-Stevenson (bib1) 1991; 64 Folkman, Klagsbrun (bib3) 1987; 235 Ferrara, Carver-Moore, Chen, Dowd, Lu, O'Shea, Powell-Braxton, Hillan, Moore (bib20) 1996; 380 Plate, Risau (bib50) 1995; 15 Carmeliet, Ferreira, Breier, Pollefeyt, Kieckens, Gertsenstein, Fahrig, Vandenhoeck, Harpal, Eberhardt, Declercq, Pawling, Moons, Collen, Risau, Nagy (bib19) 1996; 380 Kohn, Alessandro, Spoonster, Wersto, Liotta (bib2) 1995; 92 Maglione, Guerriero, Viglietto, Delli-Bovi, Persico (bib13) 1991; 88 Yoon, Park, Lim, Hwang (bib46) 1996; 222 Asano, Yukita, Matsumoto, Kondo, Suzuki (bib48) 1995; 55 Fong, Rossant, Gertsenstein, Breitman (bib17) 1995; 376 Jaffe, Nachman, Becker, Minick (bib29) 1973; 52 Fiebich, Jager, Schollmann, Weindel, Wilting, Kochs, Marme, Hug, Weich (bib43) 1993; 211 Myoken, Kayada, Okamoto, Kan, Sato, Sato (bib36) 1991; 88 Kondo, Asano, Suzuki (bib31) 1993; 194 Maciag, Cerundolo, Ilsley, Kelley, Forand (bib35) 1979; 76 Skobe, Rockwell, Goldstein, Vosseler, Fusenig (bib6) 1997; 3 Plouet, Schilling, Gospodarowicz (bib10) 1989; 8 Bresalier, Niv, Byrd, Duh, Toribara, Rockwell, Dahiya, Kim (bib34) 1991; 87 Dooley, Houghten (bib53) 1993; 52 Gho, Lee, Oh, Bae, Chae (bib26) 1997; 57 Tischer, Mitchell, Hartman, Silva, Gospodarowicz, Fiddes, Abraham (bib14) 1991; 266 Kolch, Martiny-Baron, Kieser, Marme (bib49) 1995; 36 Goldman, Kendall, Cabrera, Soroceanu, Heike, Gillespie, Siegal, Mao, Bett, Huckle, Thomas, Curiel (bib23) 1998; 95 Gengrinovitch, Greenberg, Cohen, Gitay-Goren, Rockwell, Maione, Levi, Neufeld (bib37) 1996; 270 Millauer, Shawver, Plate, Risau, Ullrich (bib24) 1994; 367 Houghten, Appel, Blondelle, Cuervo, Dooley, Pinilla (bib52) 1992; 13 Shalaby, Rossant, Yamaguch, Gertsenstein, Wu, Breitman, Schuh (bib18) 1995; 376 Jakob, Jentzsch, Mauersberger, Heder (bib32) 1978; 15 Folkman (bib33) 1974; 34 Keck, Hauser, Krivi, Sanzo, Warren, Feder, Connolly (bib12) 1989; 246 Christinger, Muller, Berleau, Keyt, Cunningham, Ferrara, de Vos (bib41) 1996; 26 De Vries, Escobedo, Ueno, Houck, Ferrara, Williams (bib16) 1992; 255 Leung, Cachianes, Kuang, Goeddel, Frrrara (bib9) 1989; 246 Risau (bib4) 1997; 386 Cohen, Gitay-Goren, Sharon, Shibuya, Halaban, Levi, Neufeld (bib40) 1995; 270 Mihich, Croce (bib47) 1999; 59 Connolly, Olander, Heuvelman, Nelson, Monsell, Siegel, Haymore, Leimgruber, Feder (bib42) 1989; 264 Millauer, Wizigmann-Voos, Schnurch, Martinez, Moller, Risau, Ullrich (bib15) 1993; 72 Christinger (10.1074/jbc.275.18.13588_bib41) 1996; 26 Dooley (10.1074/jbc.275.18.13588_bib53) 1993; 52 Keck (10.1074/jbc.275.18.13588_bib12) 1989; 246 Kondo (10.1074/jbc.275.18.13588_bib31) 1993; 194 Bresalier (10.1074/jbc.275.18.13588_bib34) 1991; 87 Plate (10.1074/jbc.275.18.13588_bib50) 1995; 15 Folkman (10.1074/jbc.275.18.13588_bib3) 1987; 235 Gospodarowicz (10.1074/jbc.275.18.13588_bib8) 1989; 86 Park (10.1074/jbc.275.18.13588_bib27) 1997; 138 Connolly (10.1074/jbc.275.18.13588_bib42) 1989; 264 Maglione (10.1074/jbc.275.18.13588_bib13) 1991; 88 Mihich (10.1074/jbc.275.18.13588_bib47) 1999; 59 Maciag (10.1074/jbc.275.18.13588_bib35) 1979; 76 Shalaby (10.1074/jbc.275.18.13588_bib18) 1995; 376 Plouet (10.1074/jbc.275.18.13588_bib10) 1989; 8 Skobe (10.1074/jbc.275.18.13588_bib6) 1997; 3 Gengrinovitch (10.1074/jbc.275.18.13588_bib37) 1996; 270 Cohen (10.1074/jbc.275.18.13588_bib40) 1995; 270 Houghten (10.1074/jbc.275.18.13588_bib52) 1992; 13 Millauer (10.1074/jbc.275.18.13588_bib24) 1994; 367 Siemeister (10.1074/jbc.275.18.13588_bib30) 1996; 222 Taylor (10.1074/jbc.275.18.13588_bib44) 1982; 297 Asano (10.1074/jbc.275.18.13588_bib48) 1995; 55 Ferrara (10.1074/jbc.275.18.13588_bib20) 1996; 380 Kolch (10.1074/jbc.275.18.13588_bib49) 1995; 36 Bussolino (10.1074/jbc.275.18.13588_bib7) 1997; 22 Leung (10.1074/jbc.275.18.13588_bib9) 1989; 246 Folkman (10.1074/jbc.275.18.13588_bib45) 1989; 339 Myoken (10.1074/jbc.275.18.13588_bib36) 1991; 88 Millauer (10.1074/jbc.275.18.13588_bib15) 1993; 72 Jakob (10.1074/jbc.275.18.13588_bib32) 1978; 15 Folkman (10.1074/jbc.275.18.13588_bib33) 1974; 34 Kim (10.1074/jbc.275.18.13588_bib22) 1993; 362 Tischer (10.1074/jbc.275.18.13588_bib14) 1991; 266 Fong (10.1074/jbc.275.18.13588_bib17) 1995; 376 Liotta (10.1074/jbc.275.18.13588_bib1) 1991; 64 Goldman (10.1074/jbc.275.18.13588_bib23) 1998; 95 Hanahan (10.1074/jbc.275.18.13588_bib5) 1996; 86 Jaffe (10.1074/jbc.275.18.13588_bib29) 1973; 52 Conn (10.1074/jbc.275.18.13588_bib11) 1990; 87 De Blasi (10.1074/jbc.275.18.13588_bib39) 1989; 10 Kohn (10.1074/jbc.275.18.13588_bib2) 1995; 92 Martiny-Baron (10.1074/jbc.275.18.13588_bib25) 1995; 6 Risau (10.1074/jbc.275.18.13588_bib4) 1997; 386 Zhang (10.1074/jbc.275.18.13588_bib21) 1995; 87 Carmeliet (10.1074/jbc.275.18.13588_bib19) 1996; 380 De Vries (10.1074/jbc.275.18.13588_bib16) 1992; 255 Bikfalvi (10.1074/jbc.275.18.13588_bib38) 1991; 149 Gho (10.1074/jbc.275.18.13588_bib26) 1997; 57 Dvorak (10.1074/jbc.275.18.13588_bib51) 1995; 146 Yoon (10.1074/jbc.275.18.13588_bib46) 1996; 222 Pinilla (10.1074/jbc.275.18.13588_bib28) 1992; 13 Fiebich (10.1074/jbc.275.18.13588_bib43) 1993; 211 |
References_xml | – volume: 380 start-page: 435 year: 1996 end-page: 439 ident: bib19 publication-title: Nature contributor: fullname: Nagy – volume: 92 start-page: 1307 year: 1995 end-page: 1311 ident: bib2 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Liotta – volume: 222 start-page: 694 year: 1996 end-page: 699 ident: bib46 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Hwang – volume: 13 start-page: 901 year: 1992 end-page: 905 ident: bib28 publication-title: BioTechniques contributor: fullname: Houghten – volume: 52 start-page: 2745 year: 1973 end-page: 2756 ident: bib29 publication-title: J. Clin. Invest. contributor: fullname: Minick – volume: 22 start-page: 251 year: 1997 end-page: 256 ident: bib7 publication-title: Trends Biochem. Sci. contributor: fullname: Persico – volume: 211 start-page: 19 year: 1993 end-page: 26 ident: bib43 publication-title: Eur. J. Biochem. contributor: fullname: Weich – volume: 13 start-page: 412 year: 1992 end-page: 421 ident: bib52 publication-title: BioTechniques contributor: fullname: Pinilla – volume: 59 start-page: 491 year: 1999 end-page: 497 ident: bib47 publication-title: Cancer Res. contributor: fullname: Croce – volume: 297 start-page: 307 year: 1982 end-page: 312 ident: bib44 publication-title: Nature contributor: fullname: Folkman – volume: 87 start-page: 213 year: 1995 end-page: 219 ident: bib21 publication-title: J. Natl. Cancer. Inst. contributor: fullname: Bicknell – volume: 15 start-page: 241 year: 1978 end-page: 249 ident: bib32 publication-title: Exp. Pathol. contributor: fullname: Heder – volume: 87 start-page: 1037 year: 1991 end-page: 1045 ident: bib34 publication-title: J. Clin. Invest. contributor: fullname: Kim – volume: 76 start-page: 5674 year: 1979 end-page: 5678 ident: bib35 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Forand – volume: 380 start-page: 439 year: 1996 end-page: 442 ident: bib20 publication-title: Nature contributor: fullname: Moore – volume: 270 start-page: 11322 year: 1995 end-page: 11326 ident: bib40 publication-title: J. Biol. Chem. contributor: fullname: Neufeld – volume: 266 start-page: 11947 year: 1991 end-page: 11954 ident: bib14 publication-title: J. Biol. Chem. contributor: fullname: Abraham – volume: 376 start-page: 62 year: 1995 end-page: 66 ident: bib18 publication-title: Nature contributor: fullname: Schuh – volume: 138 start-page: 617 year: 1997 end-page: 626 ident: bib27 publication-title: Endocrinology contributor: fullname: Chae – volume: 88 start-page: 9267 year: 1991 end-page: 9271 ident: bib13 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Persico – volume: 255 start-page: 989 year: 1992 end-page: 991 ident: bib16 publication-title: Science contributor: fullname: Williams – volume: 362 start-page: 841 year: 1993 end-page: 844 ident: bib22 publication-title: Nature contributor: fullname: Ferrara – volume: 246 start-page: 1306 year: 1989 end-page: 1309 ident: bib9 publication-title: Science contributor: fullname: Frrrara – volume: 86 start-page: 7311 year: 1989 end-page: 7315 ident: bib8 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Schilling – volume: 86 start-page: 353 year: 1996 end-page: 364 ident: bib5 publication-title: Cell contributor: fullname: Folkman – volume: 8 start-page: 3801 year: 1989 end-page: 3806 ident: bib10 publication-title: EMBO J. contributor: fullname: Gospodarowicz – volume: 88 start-page: 5819 year: 1991 end-page: 5823 ident: bib36 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Sato – volume: 386 start-page: 671 year: 1997 end-page: 674 ident: bib4 publication-title: Nature contributor: fullname: Risau – volume: 87 start-page: 2628 year: 1990 end-page: 2632 ident: bib11 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Thomas – volume: 55 start-page: 5296 year: 1995 end-page: 5301 ident: bib48 publication-title: Cancer Res. contributor: fullname: Suzuki – volume: 36 start-page: 139 year: 1995 end-page: 155 ident: bib49 publication-title: Breast Cancer Res. Treat. contributor: fullname: Marme – volume: 376 start-page: 66 year: 1995 end-page: 70 ident: bib17 publication-title: Nature contributor: fullname: Breitman – volume: 367 start-page: 576 year: 1994 end-page: 579 ident: bib24 publication-title: Nature contributor: fullname: Ullrich – volume: 95 start-page: 8795 year: 1998 end-page: 8800 ident: bib23 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Curiel – volume: 3 start-page: 1222 year: 1997 end-page: 1227 ident: bib6 publication-title: Nat. Med. contributor: fullname: Fusenig – volume: 235 start-page: 442 year: 1987 end-page: 447 ident: bib3 publication-title: Science contributor: fullname: Klagsbrun – volume: 6 start-page: 675 year: 1995 end-page: 680 ident: bib25 publication-title: Curr. Opin. Biotechnol. contributor: fullname: Marme – volume: 72 start-page: 835 year: 1993 end-page: 846 ident: bib15 publication-title: Cell contributor: fullname: Ullrich – volume: 149 start-page: 50 year: 1991 end-page: 59 ident: bib38 publication-title: J. Cell. Physiol. contributor: fullname: Tobelem – volume: 57 start-page: 3733 year: 1997 end-page: 3740 ident: bib26 publication-title: Cancer Res. contributor: fullname: Chae – volume: 15 start-page: 339 year: 1995 end-page: 347 ident: bib50 publication-title: Glia contributor: fullname: Risau – volume: 264 start-page: 20017 year: 1989 end-page: 20024 ident: bib42 publication-title: J. Biol. Chem. contributor: fullname: Feder – volume: 194 start-page: 1234 year: 1993 end-page: 1241 ident: bib31 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Suzuki – volume: 270 start-page: 15059 year: 1996 end-page: 15065 ident: bib37 publication-title: J. Biol. Chem. contributor: fullname: Neufeld – volume: 52 start-page: 1509 year: 1993 end-page: 1517 ident: bib53 publication-title: Life Sci. contributor: fullname: Houghten – volume: 339 start-page: 58 year: 1989 end-page: 61 ident: bib45 publication-title: Nature contributor: fullname: Hanahan – volume: 64 start-page: 327 year: 1991 end-page: 336 ident: bib1 publication-title: Cell contributor: fullname: Stetler-Stevenson – volume: 222 start-page: 249 year: 1996 end-page: 255 ident: bib30 publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Martiny-Baron – volume: 10 start-page: 227 year: 1989 end-page: 229 ident: bib39 publication-title: Trends Pharmacol. Sci. contributor: fullname: Motulsky – volume: 26 start-page: 353 year: 1996 end-page: 357 ident: bib41 publication-title: Proteins contributor: fullname: de Vos – volume: 146 start-page: 1029 year: 1995 end-page: 1039 ident: bib51 publication-title: Am. J. Pathol. contributor: fullname: Dvorak – volume: 246 start-page: 1309 year: 1989 end-page: 1312 ident: bib12 publication-title: Science contributor: fullname: Connolly – volume: 34 start-page: 2109 year: 1974 end-page: 2113 ident: bib33 publication-title: Cancer Res. contributor: fullname: Folkman – volume: 59 start-page: 491 year: 1999 ident: 10.1074/jbc.275.18.13588_bib47 publication-title: Cancer Res. contributor: fullname: Mihich – volume: 13 start-page: 412 year: 1992 ident: 10.1074/jbc.275.18.13588_bib52 publication-title: BioTechniques contributor: fullname: Houghten – volume: 138 start-page: 617 year: 1997 ident: 10.1074/jbc.275.18.13588_bib27 publication-title: Endocrinology doi: 10.1210/endo.138.2.4953 contributor: fullname: Park – volume: 86 start-page: 353 year: 1996 ident: 10.1074/jbc.275.18.13588_bib5 publication-title: Cell doi: 10.1016/S0092-8674(00)80108-7 contributor: fullname: Hanahan – volume: 26 start-page: 353 year: 1996 ident: 10.1074/jbc.275.18.13588_bib41 publication-title: Proteins doi: 10.1002/(SICI)1097-0134(199611)26:3<353::AID-PROT9>3.0.CO;2-E contributor: fullname: Christinger – volume: 297 start-page: 307 year: 1982 ident: 10.1074/jbc.275.18.13588_bib44 publication-title: Nature doi: 10.1038/297307a0 contributor: fullname: Taylor – volume: 64 start-page: 327 year: 1991 ident: 10.1074/jbc.275.18.13588_bib1 publication-title: Cell doi: 10.1016/0092-8674(91)90642-C contributor: fullname: Liotta – volume: 8 start-page: 3801 year: 1989 ident: 10.1074/jbc.275.18.13588_bib10 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1989.tb08557.x contributor: fullname: Plouet – volume: 339 start-page: 58 year: 1989 ident: 10.1074/jbc.275.18.13588_bib45 publication-title: Nature doi: 10.1038/339058a0 contributor: fullname: Folkman – volume: 266 start-page: 11947 year: 1991 ident: 10.1074/jbc.275.18.13588_bib14 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)99049-6 contributor: fullname: Tischer – volume: 10 start-page: 227 year: 1989 ident: 10.1074/jbc.275.18.13588_bib39 publication-title: Trends Pharmacol. Sci. doi: 10.1016/0165-6147(89)90266-6 contributor: fullname: De Blasi – volume: 376 start-page: 66 year: 1995 ident: 10.1074/jbc.275.18.13588_bib17 publication-title: Nature doi: 10.1038/376066a0 contributor: fullname: Fong – volume: 380 start-page: 439 year: 1996 ident: 10.1074/jbc.275.18.13588_bib20 publication-title: Nature doi: 10.1038/380439a0 contributor: fullname: Ferrara – volume: 362 start-page: 841 year: 1993 ident: 10.1074/jbc.275.18.13588_bib22 publication-title: Nature doi: 10.1038/362841a0 contributor: fullname: Kim – volume: 211 start-page: 19 year: 1993 ident: 10.1074/jbc.275.18.13588_bib43 publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1993.tb19865.x contributor: fullname: Fiebich – volume: 87 start-page: 1037 year: 1991 ident: 10.1074/jbc.275.18.13588_bib34 publication-title: J. Clin. Invest. doi: 10.1172/JCI115063 contributor: fullname: Bresalier – volume: 380 start-page: 435 year: 1996 ident: 10.1074/jbc.275.18.13588_bib19 publication-title: Nature doi: 10.1038/380435a0 contributor: fullname: Carmeliet – volume: 146 start-page: 1029 year: 1995 ident: 10.1074/jbc.275.18.13588_bib51 publication-title: Am. J. Pathol. contributor: fullname: Dvorak – volume: 72 start-page: 835 year: 1993 ident: 10.1074/jbc.275.18.13588_bib15 publication-title: Cell doi: 10.1016/0092-8674(93)90573-9 contributor: fullname: Millauer – volume: 87 start-page: 2628 year: 1990 ident: 10.1074/jbc.275.18.13588_bib11 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.87.7.2628 contributor: fullname: Conn – volume: 270 start-page: 11322 year: 1995 ident: 10.1074/jbc.275.18.13588_bib40 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.19.11322 contributor: fullname: Cohen – volume: 92 start-page: 1307 year: 1995 ident: 10.1074/jbc.275.18.13588_bib2 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.92.5.1307 contributor: fullname: Kohn – volume: 235 start-page: 442 year: 1987 ident: 10.1074/jbc.275.18.13588_bib3 publication-title: Science doi: 10.1126/science.2432664 contributor: fullname: Folkman – volume: 57 start-page: 3733 year: 1997 ident: 10.1074/jbc.275.18.13588_bib26 publication-title: Cancer Res. contributor: fullname: Gho – volume: 95 start-page: 8795 year: 1998 ident: 10.1074/jbc.275.18.13588_bib23 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.95.15.8795 contributor: fullname: Goldman – volume: 270 start-page: 15059 year: 1996 ident: 10.1074/jbc.275.18.13588_bib37 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.25.15059 contributor: fullname: Gengrinovitch – volume: 264 start-page: 20017 year: 1989 ident: 10.1074/jbc.275.18.13588_bib42 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)47212-8 contributor: fullname: Connolly – volume: 87 start-page: 213 year: 1995 ident: 10.1074/jbc.275.18.13588_bib21 publication-title: J. Natl. Cancer. Inst. doi: 10.1093/jnci/87.3.213 contributor: fullname: Zhang – volume: 246 start-page: 1306 year: 1989 ident: 10.1074/jbc.275.18.13588_bib9 publication-title: Science doi: 10.1126/science.2479986 contributor: fullname: Leung – volume: 88 start-page: 9267 year: 1991 ident: 10.1074/jbc.275.18.13588_bib13 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.88.20.9267 contributor: fullname: Maglione – volume: 376 start-page: 62 year: 1995 ident: 10.1074/jbc.275.18.13588_bib18 publication-title: Nature doi: 10.1038/376062a0 contributor: fullname: Shalaby – volume: 22 start-page: 251 year: 1997 ident: 10.1074/jbc.275.18.13588_bib7 publication-title: Trends Biochem. Sci. doi: 10.1016/S0968-0004(97)01074-8 contributor: fullname: Bussolino – volume: 255 start-page: 989 year: 1992 ident: 10.1074/jbc.275.18.13588_bib16 publication-title: Science doi: 10.1126/science.1312256 contributor: fullname: De Vries – volume: 367 start-page: 576 year: 1994 ident: 10.1074/jbc.275.18.13588_bib24 publication-title: Nature doi: 10.1038/367576a0 contributor: fullname: Millauer – volume: 86 start-page: 7311 year: 1989 ident: 10.1074/jbc.275.18.13588_bib8 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.86.19.7311 contributor: fullname: Gospodarowicz – volume: 386 start-page: 671 year: 1997 ident: 10.1074/jbc.275.18.13588_bib4 publication-title: Nature doi: 10.1038/386671a0 contributor: fullname: Risau – volume: 222 start-page: 249 year: 1996 ident: 10.1074/jbc.275.18.13588_bib30 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1996.0730 contributor: fullname: Siemeister – volume: 13 start-page: 901 year: 1992 ident: 10.1074/jbc.275.18.13588_bib28 publication-title: BioTechniques contributor: fullname: Pinilla – volume: 15 start-page: 241 year: 1978 ident: 10.1074/jbc.275.18.13588_bib32 publication-title: Exp. Pathol. contributor: fullname: Jakob – volume: 15 start-page: 339 year: 1995 ident: 10.1074/jbc.275.18.13588_bib50 publication-title: Glia doi: 10.1002/glia.440150313 contributor: fullname: Plate – volume: 55 start-page: 5296 year: 1995 ident: 10.1074/jbc.275.18.13588_bib48 publication-title: Cancer Res. contributor: fullname: Asano – volume: 149 start-page: 50 year: 1991 ident: 10.1074/jbc.275.18.13588_bib38 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.1041490108 contributor: fullname: Bikfalvi – volume: 36 start-page: 139 year: 1995 ident: 10.1074/jbc.275.18.13588_bib49 publication-title: Breast Cancer Res. Treat. doi: 10.1007/BF00666036 contributor: fullname: Kolch – volume: 6 start-page: 675 year: 1995 ident: 10.1074/jbc.275.18.13588_bib25 publication-title: Curr. Opin. Biotechnol. doi: 10.1016/0958-1669(95)80111-1 contributor: fullname: Martiny-Baron – volume: 76 start-page: 5674 year: 1979 ident: 10.1074/jbc.275.18.13588_bib35 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.76.11.5674 contributor: fullname: Maciag – volume: 88 start-page: 5819 year: 1991 ident: 10.1074/jbc.275.18.13588_bib36 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.88.13.5819 contributor: fullname: Myoken – volume: 194 start-page: 1234 year: 1993 ident: 10.1074/jbc.275.18.13588_bib31 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1993.1955 contributor: fullname: Kondo – volume: 52 start-page: 2745 year: 1973 ident: 10.1074/jbc.275.18.13588_bib29 publication-title: J. Clin. Invest. doi: 10.1172/JCI107470 contributor: fullname: Jaffe – volume: 222 start-page: 694 year: 1996 ident: 10.1074/jbc.275.18.13588_bib46 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1996.0806 contributor: fullname: Yoon – volume: 34 start-page: 2109 year: 1974 ident: 10.1074/jbc.275.18.13588_bib33 publication-title: Cancer Res. contributor: fullname: Folkman – volume: 3 start-page: 1222 year: 1997 ident: 10.1074/jbc.275.18.13588_bib6 publication-title: Nat. Med. doi: 10.1038/nm1197-1222 contributor: fullname: Skobe – volume: 246 start-page: 1309 year: 1989 ident: 10.1074/jbc.275.18.13588_bib12 publication-title: Science doi: 10.1126/science.2479987 contributor: fullname: Keck – volume: 52 start-page: 1509 year: 1993 ident: 10.1074/jbc.275.18.13588_bib53 publication-title: Life Sci. doi: 10.1016/0024-3205(93)90113-H contributor: fullname: Dooley |
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SubjectTerms | Amino Acid Sequence Animals Arginine Endothelial Growth Factors - antagonists & inhibitors hexapeptides Humans Lymphokines - antagonists & inhibitors Mice Molecular Sequence Data Neoplasm Metastasis - drug therapy Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Neovascularization, Pathologic - drug therapy Peptide Library Peptides - chemistry Peptides - genetics Peptides - pharmacology Peptides - therapeutic use Rabbits Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
Title | Arginine-rich Anti-vascular Endothelial Growth Factor Peptides Inhibit Tumor Growth and Metastasis by Blocking Angiogenesis |
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