rpoB Mutations Causing Discordant Rifampicin Susceptibility in Mycobacterium tuberculosis : Retrospective Analysis of Prevalence, Phenotypic, Genotypic, and Treatment Outcomes

• Published in: Open forum infectious diseases Vol. 6; no. 4; p. ofz065
• Main Authors: Mvelase, Nomonde R, Pillay, Melendhran, Sibanda, Wilbert, Ngozo, Jacqueline N, Brust, James C M, Mlisana, Koleka P
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2019
• Subjects: Major; rpoB mutations; rifampicin; discordant; TB

Discordant genotypic/phenotypic rifampicin susceptibility testing in is a significant challenge, yet there are limited data on its prevalence and how best to manage such patients. Whether to treat isolates with mutations not conferring phenotypic resistance as susceptible or multidrug-resistant tube...