Antibody Fc Glycosylation Discriminates Between Latent and Active Tuberculosis

• Published in: The Journal of infectious diseases Vol. 222; no. 12; pp. 2093 - 2102
• Main Authors: Lu, Lenette L, Das, Jishnu, Grace, Patricia S, Fortune, Sarah M, Restrepo, Blanca I, Alter, Galit
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15.12.2020
• Subjects: Acyltransferases - analysis; Adolescent; Adult; Aged; Antibodies; Antigens; Antigens, Bacterial - analysis; Bacterial Proteins - analysis; Cell activation; Cytotoxicity; Electrophoresis, Capillary; Fab; Female; Glycosylation; Humans; Immunoglobulin Fab Fragments - chemistry; Immunoglobulin Fc Fragments - chemistry; Immunoglobulin G; Immunoglobulin G - analysis; Latent infection; Latent Tuberculosis - diagnosis; Major and Brief Reports; Male; Medical diagnosis; Middle Aged; Multivariate analysis; Mycobacterium tuberculosis; Natural killer cells; Phagocytosis; Polysaccharides; Polysaccharides - analysis; Public health; Tuberculin; Tuberculin - analysis; Tuberculosis; Tuberculosis - diagnosis; glycosylation; diagnostics; antibodies; tuberculosis; Fc effector function

Abstract Background Mycobacterium tuberculosis remains a global health problem and clinical management is complicated by difficulty in discriminating between latent infection and active disease. While M. tuberculosis-reactive antibody levels are heterogeneous, studies suggest that levels of IgG glyc...