KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy

• Published in: Genes Vol. 12; no. 3; p. 408
• Main Authors: Li, Ning, Xu, Ying-Jia, Shi, Hong-Yu, Yang, Chen-Xi, Guo, Yu-Han, Li, Ruo-Gu, Qiu, Xing-Biao, Yang, Yi-Qing, Zhang, Min
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.03.2021; MDPI
• Subjects: Arrhythmia; atrial fibrillation; Binding sites; bioinformatics; Cardiac arrhythmia; Cardiomyopathy; Cardiovascular disease; Congestive heart failure; Connective tissue growth factor; death; Deoxyribonucleic acid; DNA; DNA polymerase; Electrocardiography; Electrophysiology; Enzymes; Fibrillation; Gene expression; genes; genetic heterogeneity; Genomes; Growth factors; Heart; heart failure; heterozygosity; Hospitals; Laboratories; loss-of-function mutation; Molecular modelling; Mutagenesis; mutants; Mutation; pathogenesis; pedigree; penetrance; Plasmids; Polymorphism; Potassium channels (voltage-gated); stroke; transcription (genetics); Transcription activation; transcription factors; transcriptional activation; Transforming growth factor-b1; Ventricle; United States > US; transcription factor; atrial fibrillation; genetics; cardiomyopathy; KLF15; arrhythmia

Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia and substantially increases the risks of cerebral stroke, heart failure and death. Accumulating evidence has convincingly demonstrated the strong genetic basis of AF, and an increasing number of pathogenic variat...