Human Mesenchymal Stem Cells Modulate Inflammatory Cytokines after Spinal Cord Injury in Rat

• Published in: International journal of molecular sciences Vol. 15; no. 7; pp. 11275 - 11293
• Main Authors: Urdzíková, Lucia, Růžička, Jiří, LaBagnara, Michael, Kárová, Kristýna, Kubinová, Šárka, Jiráková, Klára, Murali, Raj, Syková, Eva, Jhanwar-Uniyal, Meena, Jendelová, Pavla
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.06.2014; MDPI
• Subjects: Animals; Chemokine CCL5 - genetics; Chemokine CCL5 - metabolism; Cytokines; Fibroblast Growth Factor 2 - genetics; Fibroblast Growth Factor 2 - metabolism; GAP-43 Protein - genetics; GAP-43 Protein - metabolism; Glial Fibrillary Acidic Protein - genetics; Glial Fibrillary Acidic Protein - metabolism; Humans; Interferon Regulatory Factors - genetics; Interferon Regulatory Factors - metabolism; Interleukins - genetics; Interleukins - metabolism; Locomotion; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells - metabolism; Protein expression; Rats; Rats, Wistar; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Rodents; Spinal cord injuries; Spinal Cord Injuries - metabolism; Spinal Cord Injuries - therapy; Stem cells; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism

Transplantation of mesenchymal stem cells (MSC) improves functional recovery in experimental models of spinal cord injury (SCI); however, the mechanisms underlying this effect are not completely understood. We investigated the effect of intrathecal implantation of human MSC on functional recovery, a...