The Laboratory Domestication of Zebrafish: From Diverse Populations to Inbred Substrains

• Published in: Molecular biology and evolution Vol. 37; no. 4; pp. 1056 - 1069
• Main Authors: Suurväli, Jaanus, Whiteley, Andrew R, Zheng, Yichen, Gharbi, Karim, Leptin, Maria, Wiehe, Thomas
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2020
• Subjects: Animal models; Animals; Animals, Inbred Strains; Animals, Wild - genetics; Archives & records; Biomedical research; Danio rerio; Developmental biology; Discoveries; DNA sequencing; Domestication; Evolution; Fish; Frequency spectrum; Gene conversion; Gene Frequency; Gene sequencing; Genes; Genetic diversity; Genetic Variation; Genetics; Genome; Genomes; Genomics; Heterozygosity; In vivo methods and tests; Inbreeding; Laboratories; Laboratory animals; Nucleotides; Physiology; Population genetics; Population studies; Populations; Precision medicine; Species diversity; Vertebrates; Zebrafish; Zebrafish - genetics; Bangladesh; Nepal; genetic diversity; laboratory strains; RAD-seq; genetic differentiation; zebrafish; inbreeding; wild populations

We know from human genetic studies that practically all aspects of biology are strongly influenced by the genetic background, as reflected in the advent of “personalized medicine.” Yet, with few exceptions, this is not taken into account when using laboratory populations as animal model systems for...