Dietary intake and risk assessment of phototoxic furocoumarins in humans

• Published in: Food and chemical toxicology Vol. 29; no. 8; pp. 523 - 530
• Main Authors: Schlatter, J., Zimmerli, B., Dick, R., Panizzon, R., Schlatter, Ch
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1991; New York, NY Elsevier Science
• Subjects: 5-Methoxypsoralen; administration & dosage; Administration, Oral; adverse effects; Biological and medical sciences; blood; chemically induced; Chromatography, High Pressure Liquid; coumarins; diet; Food toxicology; Furocoumarins; Furocoumarins - blood; Humans; Male; Medical sciences; Methoxsalen; Methoxsalen - administration & dosage; Methoxsalen - adverse effects; Photosensitivity Disorders; Photosensitivity Disorders - blood; Photosensitivity Disorders - chemically induced; risk; Risk Factors; toxic substances; toxicity; Toxicology; Ultraviolet Rays; Ultraviolet Rays - adverse effects; Vegetables; 8-MOP = 8-methoxypsoralen; 5-MOP = 5-methoxypsoralen; Human; Skin disease; Root; Toxicity; Coumarine derivatives; Apium graveolens; Normal; Celery; Dicotyledones; Angiospermae; Plant origin; Phototoxicity; Spermatophyta; Umbelliferae; Vegetable; Food

The question of whether the furocoumarin content of vegetables is sufficient to induce phototoxic skin reactions after ultraviolet irradiation was examined in two experiments with four human volunteers. In a first experiment, 300 g of celery roots (total phototoxic furocoumarin content 28.2 mug/g) w...