Contribution of metabolic risk factors and lifestyle behaviors to cardiovascular disease: A mendelian randomization study

• Published in: Nutrition, metabolism, and cardiovascular diseases Vol. 32; no. 8; pp. 1972 - 1981
• Main Authors: Jia, Yiming, Wang, Rong, Guo, Daoxia, Sun, Lulu, Shi, Mengyao, Zhang, Kaixin, Yang, Pinni, Zang, Yuhan, Wang, Yu, Liu, Fanghua, Zhang, Yonghong, Zhu, Zhengbao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2022
• Subjects: alcohol abuse; alcohol drinking; blood pressure; body mass index; Cardiovascular disease; Coronary artery disease; education; etiology; glucose; high density lipoprotein cholesterol; hypertension; Ischemic stroke; lifestyle; low density lipoprotein cholesterol; Mendelian randomization; metabolism; noninsulin-dependent diabetes mellitus; nutrition; overweight; Risk factors; MR-PRESSO; RCT; GWAS; OR; LDL-C; MR; CAD; CARDIOGRAMPLUSC4D; Cardiovascular disease; Ischemic stroke; Mendelian randomization; IVW; Coronary artery disease; Risk factors; BP; CVD; HDL-C; MEGASTROKE; RSS; STROBE-MR; SNP; LD; BMI

Etiologic associations between some modifiable factors (metabolic risk factors and lifestyle behaviors) and cardiovascular disease (CVD) remain unclear. To identify targets for CVD prevention, we evaluated the causal associations of these factors with coronary artery disease (CAD) and ischemic strok...