Inhibitor κB-Like Proteins from a Polydnavirus Inhibit NF-κB Activation and Suppress the Insect Immune Response

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 32; pp. 11426 - 11431
• Main Authors: Thoetkiattikul, Honglada, Beck, Markus H., Strand, Michael R., Law, John H.
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 09.08.2005; National Acad Sciences
• Subjects: Ankyrins; Antibodies; Biological Sciences; Bracovirus; Cactus; Drosophila; Hymenoptera; Insect genetics; Insect pests; Insect proteins; Insect viruses; Microplitis demolitor; Parasite hosts; Polydnavirus; Proteins

Complex signaling pathways regulate the innate immune system of insects, with NF-κB transcription factors playing a central role in the activation of antimicrobial peptides and other immune genes. Although numerous studies have characterized the immune responses of insects to pathogens, comparativel...