Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T

• Published in: Nature communications Vol. 15; no. 1; pp. 9159 - 13
• Main Authors: Mevenkamp, Julian, Bruls, Yvonne M. H., Mancilla, Rodrigo, Grevendonk, Lotte, Wildberger, Joachim E., Brouwers, Kim, Hesselink, Matthijs K. C., Schrauwen, Patrick, Hoeks, Joris, Houtkooper, Riekelt H., Buitinga, Mijke, de Graaf, Robin A., Lindeboom, Lucas, Schrauwen-Hinderling, Vera B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 59; 59/57; 631/443/319/333/1465; 631/443/7; 639/166/985; 692/163/2743/393; Biopsy; Biosynthesis; Humanities and Social Sciences; Ischemia; Magnetic resonance imaging; Magnetic resonance spectroscopy; Metabolism; Metabolites; multidisciplinary; Muscles; NAD; NADH; Nicotinamide adenine dinucleotide; Older people; Physiological effects; Scanners; Science; Science (multidisciplinary); Skeletal muscle; Spectroscopy; Spectrum analysis

NADH and NAD + act as electron donors and acceptors and NAD + was shown to stimulate mitochondrial biogenesis and metabolic health. We here develop a non-invasive Phosphorous Magnetic Resonance Spectroscopy ( 31 P-MRS) method to quantify these metabolites in human skeletal muscle on a clinical 3 T M...